Electrospinning of spider silk‐based nanofibers
Electrospinning of spider silk‐based nanofibers
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DOI：
10.1002/pat.5719
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发表时间：
2022-05
影响因子：
3.4
通讯作者：
Kenjiro Yazawa;Saeka Mizukami;M. Aoki;Y. Tamada
中科院分区：
文献类型：
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作者：
Kenjiro Yazawa;Saeka Mizukami;M. Aoki;Y. Tamada
蜘蛛丝作为一种结构材料和下一代医疗资源，因其韧性、轻质和可生物降解而受到人们的关注。由于先进的电纺技术，非织造丝织物在研究和工业中不断涌现。一些研究已经报道了由蜘蛛丝样蛋白制成的非织造布，这种非织造布来自重组表达系统，分子量比天然同类低。较低的分子量导致缺乏机械强度和耐用性，阻碍了蜘蛛丝基非织造布作为结构和医疗材料的工业潜力的评估。在这项研究中，一种电纺非织造布是用从活蜘蛛身上强行卷取的本地蜘蛛丝纤维生产的。蜘蛛丝非织造布表现出细胞相容性，力学性能优于蚕丝非织造布。蜘蛛丝非织造布的可获得性带来了一系列尚未探索的潜在用途，以及可持续发展目标的背景。
Spider silk has garnered attention as a structural material and a medical resource for next generation because it is tough, lightweight, and biodegradable. Nonwoven silk fabrics are emerging in research and industries owing to advanced electrospinning techniques. Several studies have reported nonwoven fabrics made of spider silk‐like proteins, which are originated from recombinant expression systems, with lower molecular weights than the natural counterpart. The lower molecular weight causes a lack of mechanical strength and durability, preventing the evaluation of industrial potential of the spider silk‐based nonwoven fabric to use as a structural and medical material. In this study, an electrospun nonwoven fabric is produced using native spider silk fibers forcibly reeled from live spiders. The spider silk‐based nonwoven fabrics demonstrate cell compatibility, and the mechanical properties are superior to the silkworm silk‐based nonwoven fabrics. The availability of spider silk‐based nonwoven fabrics introduces an unexplored set of potential uses, along with the context of sustainable development goals.