Adenomatoid tumors--mesotheliomas or not? A histochemical, immunohistochemical and light and electron microscopic (TEM/SEM) study.
Adenomatoid tumors--mesotheliomas or not? A histochemical, immunohistochemical and light and electron microscopic (TEM/SEM) study.
复制标题
腺瘤样肿瘤——间皮瘤还是不是？
DOI：
--
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
D. Katenkamp
中科院分区：
文献类型：
--
作者：
H. Kosmehl;L. Langbein;D. Katenkamp
文献中讨论了腺瘤样瘤的间皮、内皮和上皮分化。针对这一问题，采用组织化学和免疫组织化学方法，在光镜和电镜水平上对12例腺瘤样肿瘤的细胞本质进行了研究。在所有这些肿瘤中，前角蛋白被证明，而因子VIII相关抗原和肌红蛋白缺乏肿瘤细胞内。肿瘤细胞的超微结构图片是类似的间皮细胞，丰富的角蛋白型的中间丝可以装饰通过蛋白A-金技术在他们。此外，还发现了透明质酸酶敏感的糖胺聚糖，但没有发现硫酸化和中性粘蛋白。
A mesothelial, endothelial and epithelial differentiation of the adenomatoid tumors is discussed in the literature. Aimed at this problem the cellular nature of 12 adenomatoid tumors was investigated by means of histochemical and immunohistochemical methods at light and electron microscopic level. In all these neoplasias prekeratin was demonstrated while factor VIII-associated antigen and myoglobin were lacking within the tumor cells. The ultrastructural picture of the tumor cells was similar to that of mesothelial cells; abundant intermediate filaments of the keratin type could be decorated by means of the protein A-gold technique in them. Furthermore hyaluronidase sensitive glycosaminoglycans but no sulfated and neutral mucoproteins were found. The results suggest a mesothelial nature of the tumor cells of adenomatoid tumors.