Pathologic characterization of Brown Norway, Brown Norway x Fischer 344, and Fischer 344 x Brown Norway rats with relation to age
Pathologic characterization of Brown Norway, Brown Norway x Fischer 344, and Fischer 344 x Brown Norway rats with relation to age
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DOI：
10.1093/gerona/51a.1.b54
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发表时间：
1996-01-01
影响因子：
5.1
通讯作者：
Bronson, RT
中科院分区：
文献类型：
--
作者：
Lipman, RD;Chrisp, CE;Bronson, RT
大鼠是一种常见的实验动物，用于各种研究，包括实验老年学。当比较年轻和年老动物时观察到的差异实际上是正常状态和疾病状态之间的差异时，老年学研究可能会受到影响。了解所研究动物的病理学并了解这些疾病过程对所测量参数的影响至关重要。损伤的发生率和平均发生年龄已被表征，并在此报告了大鼠的一种近交系（Brown挪威）和两种杂交品系（Brown挪威x Fischer 344和Fischer 344 x Brown挪威）。对于所有检查的菌株，总病变发生率可作为衰老的生物标志物（p 小于或等于 0.00001）。这三种基因型的几种主要病理过程（包括肾小球肾炎、视网膜萎缩和白血病）的发生率明显低于 Fischer 344 和 Wistar 大鼠（两种常用品系）。此外，BN 和 F344 x BN F-1 杂交大鼠分别在 130 周龄和 146 周龄时死亡率达到 50%，显着高于 F344 大鼠的 103 周龄。希望获得这三种大鼠基因型的基本信息将增加老年学科学家群体对它们的利用。
The rat is a common laboratory animal utilized in a variety of investigations including experimental gerontology. Gerontologic investigations can be compromised when the differences observed when comparing young and old animals are actually differences between normal and disease states. It is of critical interest to know the pathology of the animals being studied and to understand the impact of these disease processes on the parameters being measured. The incidence and average age of occurrence for lesions have been characterized and are reported here for ane inbred (Brown Norway) and two hybrid strains (Brown Norway x Fischer 344 and Fischer 344 x Brown Norway) of rat. Total lesion incidence functions as a biomarker of aging for all of the strains examined (p less than or equal to .00001). These three genotypes have significantly lower incidence of several major pathologic processes (including glomerulonephritis, retinal atrophy, and leukemia) than do the Fischer 344 and the Wistar rats, two commonly utilized strains. Additionally, the BN and F344 x BN F-1 hybrid attain 50% mortality at 130 and 146 weeks of age, respectively, which is significantly greater than the 103 weeks for the F344 rat. It is hoped that access to basic information on these three rat genotypes will increase their utilization by the community of gerontologic scientists.