Paraventricular nucleus CRH neurons encode stress controllability and regulate defensive behavior selection
Paraventricular nucleus CRH neurons encode stress controllability and regulate defensive behavior selection
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DOI：
10.1038/s41593-020-0591-0
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发表时间：
2020-02-17
影响因子：
25
通讯作者：
Bains, Jaideep S.
中科院分区：
文献类型：
--
作者：
Daviu, Nuria;Fuzesi, Tamas;Bains, Jaideep S.
即使在不同的情况下，先前的压力经历也会影响随后的行为。Daviu等人证明，CRHPVN神经元编码应激可控性，并有助于主动和被动先天防御策略之间的转换。在人类和啮齿动物中，应激事件期间的控制感知具有持久的行为后果。即使在与压力情境不同的情况下，这些后果也是显而易见的，但大脑如何将先前的压力体验与随后的行为联系起来仍然知之甚少。通过评估先天防御行为的隐现阴影任务，我们表明，启动逃避反应之前的促肾上腺皮质激素释放激素（CRH）神经元的活动增加室旁核（PVN）的下丘脑（CRHPVN神经元）。这种预期性增长对具有高或低水平结果控制的压力刺激敏感。具体来说，高结果控制的实验应激增加CRHPVN神经元的预期活动，这增加了在不相关的情况下的逃避行为。相比之下，没有结果控制的压力会阻止这种预期活动的出现，并减少随后的逃避行为。这些观察结果表明，CRHPVN神经元编码应激可控性，并有助于主动和被动先天防御策略之间的转变。
Prior stressful experience affects subsequent behavior even in different situations. Daviu et al. demonstrate that CRHPVN neurons encode stress controllability and contribute to shifts between active and passive innate defensive strategies.In humans and rodents, the perception of control during stressful events has lasting behavioral consequences. These consequences are apparent even in situations that are distinct from the stress context, but how the brain links prior stressful experience to subsequent behaviors remains poorly understood. By assessing innate defensive behavior in a looming-shadow task, we show that the initiation of an escape response is preceded by an increase in the activity of corticotropin-releasing hormone (CRH) neurons in the paraventricular nucleus (PVN) of the hypothalamus (CRHPVN neurons). This anticipatory increase is sensitive to stressful stimuli that have high or low levels of outcome control. Specifically, experimental stress with high outcome control increases CRHPVN neuron anticipatory activity, which increases escape behavior in an unrelated context. By contrast, stress with no outcome control prevents the emergence of this anticipatory activity and decreases subsequent escape behavior. These observations indicate that CRHPVN neurons encode stress controllability and contribute to shifts between active and passive innate defensive strategies.