Distribution of tetracycline resistance genes teit(M), tet(O), tet(L) and tet(K) in blood isolates of viridans group streptococci harbouring erm(B) and mef(A) genes.: Susceptibility to quinupristin/dalfopristin and linezolid
Distribution of tetracycline resistance genes teit(M), tet(O), tet(L) and tet(K) in blood isolates of viridans group streptococci harbouring erm(B) and mef(A) genes.: Susceptibility to quinupristin/dalfopristin and linezolid
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DOI：
10.1016/s0924-8579(03)00062-1
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发表时间：
2003-06-01
影响因子：
10.8
通讯作者：
Picazo, JJ
中科院分区：
文献类型：
--
作者：
Rodriguez-Avial, I;Rodriguez-Avial, C;Picazo, JJ
使用111株连续非重复的草绿色链球菌（VGS）血培养分离株研究了对红霉素、四环素、克林霉素、奎奴普汀/达福普汀和利奈唑胺的敏感性。在47株（42%）红霉素耐药菌株中检测到单独或联合的mef（B）和mef（A）基因。四环素耐药菌株中，泰特（M）基因占78%（36/35）。两个分离株单独携带泰特（O）基因，另外两个分离株携带与泰特（O）或泰特（M）相关的泰特（L）基因。红霉素和四环素耐药之间的关联是常见的，并且在我们的VGS中似乎与红霉素（B）和泰特（M）决定簇相关。我们发现3株耐奎奴普汀/达福普汀的菌株，它们都是红霉素和四环素耐药。对于检测的所有分离株，利奈唑胺MIC均< 2 mg/l。(C)2003年Elsevier Science B. V.和国际化疗学会。All rights reserved.
Susceptibility to erythromycin, tetracycline, clindamycin, quinupristin/dalfopristin and linezolid was investigated using 111 consecutive non-duplicate blood culture isolates of viridans-group streptococci (VGS). The erm (B) and mef(A) genes were detected, either alone or in combination, in the 47 (42%) erythromycin-resistant strains. The tet(M) gene alone was predominant (78%) in the 36 (35%) tetracycline-resistant isolates. Two isolates carried the tet(O) gene alone and two others the tet(L) associated with tet(O) or tet(M). The association between erythromycin and tetracycline resistance was common and the erm(B) and tet(M) determinants seem to be associated in our VGS. We found three isolates resistant to quinupristin/dalfopristin, all of them were erythromycin and tetracycline-resistant. For all isolates tested, linezolid MICs were < 2 mg/l. (C) 2003 Elsevier Science B.V. and the International Society of Chemotherapy. All rights reserved.