New addition to the statin's effect
New addition to the statin's effect
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DOI：
10.1097/01.ta.0000240974.07999.bc
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发表时间：
2007-07-01
影响因子：
--
通讯作者：
Erdemli, Esra
中科院分区：
文献类型：
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作者：
Kiliccoglu, Sibel Serin;Erdemli, Esra
背景资料：对人类和动物模型的观察表明，他汀类药物除了降低胆固醇水平和缺血性心脏病外，还可能降低骨质疏松性骨折的风险。材料：54只大鼠随机分为对照组、辛伐他汀1 mg/d组和辛伐他汀2 mg/d组，每组10只。在氯胺酮麻醉下，我们对健康大鼠的小腿远端进行了手指操作的闭合性骨折。然后，大鼠在骨折当天每天注射一次，并在随后的4天内将辛伐他汀注射到骨折区域的皮下组织中。分别于第7、14、21天处死各组大鼠，取胫骨进行组织学观察，光镜下观察胫骨的形态学变化。结果：注射辛伐他汀组骨折进展速度快于对照组，类骨质参数差异有统计学意义（p = 0.001）。结论：辛伐他汀对骨折愈合有明显的促进作用。与对照组相比，西伐他汀治疗组骨祖细胞的形成和分化速度加快，数量增加。随着新毛细血管的形成和钙化的增加，骨折愈合加快。
Background: Observations in humans and in animal models have shown that statins, besides reducing cholesterol levels and ischemic heart disease, might also reduce the risk of osteoporotic fractures. The purpose of this study was to investigate the effects of simvastatin on fracture healing in vivo.Materials: Fifty-four rats were randomly assigned to one of three groups: the control group and the groups with two doses of 1 mg/d and 2 mg/d drug injected. We performed a closed fracture by digital manipulation on the distal leg of healthy rats under the ketamine anesthesia. Then, rats were injected one time per day on fracture day and by the following 4 days simvastatin to the fractured area into the subcutaneous tissue. On the 7th, 14th, and 21st days, rats from each group were first killed and then after the histologic observation the tibias were examined under light microscopy. Statistical analyses were performed using SPSS 11.5 package program.Results: The simvastatin-injected group went through the stages of fracture faster than the control group did and the osteoid parameter was found to be significantly different (p = 0.001). There was no clear variation between different doses.Conclusion: Sinivastatin treatment of the fractured bone showed a significant positive effect on fracture healing. In the sinivastatin treatment group the formation and differentiation of osteoprogenitor cells were increased in number and were faster than in the control group. As the formation of new capillaries and calcification increased, the healing of the fracture accelerated.