Low elastic modulus contributes to the osteointegration of titanium alloy plug.
Low elastic modulus contributes to the osteointegration of titanium alloy plug.
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DOI：
10.1002/jbm.b.32860
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发表时间：
2013-05
期刊：
影响因子：
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通讯作者：
Yong-quan Zhang;Jun-lin Wang;Pan Wang;Xiangli Fan;Xiao-kang Li;Jun Fu;Shujun Li;H. Fan;Zheng Guo
中科院分区：
文献类型：
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作者：
Yong-quan Zhang;Jun-lin Wang;Pan Wang;Xiangli Fan;Xiao-kang Li;Jun Fu;Shujun Li;H. Fan;Zheng Guo
用微型钛塞修复软骨缺损被认为是治疗局灶性软骨缺损的一种很有前途的方法。金属种植体的弹性模量对力的传递起着重要的作用，影响着种植体的稳定性。本研究评估了钛2448 （Ti2448）和钛-6铝-4钒（TAV）两种不同弹性模量的钛合金塞对骨整合的影响。在犬双侧双膝制造全层软骨缺损，分别植入TAV和Ti2448桥塞。12周后，两组放射学评估均未发现任何拆卸、下沉或假体周围透光度的迹象。显微计算机断层扫描分析显示，Ti2448组骨组织形态学参数均明显优于TAV组。此外，Ti2448组的拔牙力值也显著更高。组织学显示Ti2448牙塞螺纹与新骨融合良好。相比之下，小梁骨稀疏分布在TAV栓周围。综上所述，低弹性模量的Ti2448桥塞在骨整合中表现出更有利的特性。Ti2448可能是一种很有前途的生物材料，用于软骨表面修复的微型塞的制作。
Resurfacing of cartilage defect with mini titanium plug is considered a promising alternative for the treatment of focal chondral defects. Elastic modulus of the metal implant plays a significant role in force transmission which influences the stability of plug. This study assessed the effects of two kinds of titanium alloy plug with different elastic modulus, that is, titanium 2448 (Ti2448) plug and titanium-6 aluminum-4 vanadium (TAV) plug on osteointegration. The full-thickness chondral defects were created in bilateral knees of dogs and then TAV and Ti2448 plugs were implanted, respectively. After 12 weeks, radiographic evaluation did not reveal any signs of disassembly, subsidence, or periprosthetic radiolucency in both groups. Microcomputed tomography analysis revealed that bone histomorphometric parameters in Ti2448 group were all significantly better than those of TAV group. Furthermore, the value of pullout force in Ti2448 group was also significantly higher. Histology showed that the screw threads of Ti2448 plug were well integrated into the newly formed bone. In contrast, the trabecular bone was sparsely distributed around TAV plug. In conclusion, Ti2448 plug with low elastic modulus showed more favorable characteristics in osteointegration. Ti2448 may be a promising biomaterial for fabricating mini plug applied for cartilage resurfacing.