Characterization of microRNA-regulated protein-protein interaction network
Characterization of microRNA-regulated protein-protein interaction network
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DOI：
10.1002/pmic.200701004
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发表时间：
2008-05-01
期刊：
影响因子：
3.4
通讯作者：
Huang, Hsuan-Cheng
中科院分区：
文献类型：
--
作者：
Hsu, Chun-Wei;Juan, Hsueh-Fen;Huang, Hsuan-Cheng
我们已经进行了拓扑分析，以阐明微RNA（miRNA）的调控和蛋白质-蛋白质相互作用网络在人类之间的全局相关性。分析表明，单个miRNA的靶基因往往是网络中的枢纽和瓶颈。虽然由miRNA直接调控的蛋白质本身可能不会形成网络模块，但miRNA靶基因及其相互作用的邻居共同表现出显着更高的模块性。我们的发现揭示了miRNA如何调节蛋白质相互作用网络。
We have performed topological analysis to elucidate the global correlation between microRNA (miRNA) regulation and protein-protein interaction network in human. The analysis showed that target genes of individual miRNA tend to be hubs and bottlenecks in the network. While proteins directly regulated by miRNA might not form a network module themselves, the miRNA-target genes and their interacting neighbors jointly showed significantly higher modularity. Ourfindings shed light on how miRNA may regulate the protein interaction network.