Turnover of total carbon dioxide in the aqueous humors and the effect thereon of acetazolamide.
Turnover of total carbon dioxide in the aqueous humors and the effect thereon of acetazolamide.
复制标题
房水中总二氧化碳的周转以及乙酰唑胺对其的影响。
DOI：
10.1001/archopht.1959.04220010082009
复制
发表时间：
1959
期刊：
影响因子：
--
通讯作者：
D. Reddy
中科院分区：
文献类型：
--
作者：
V. Kinsey;D. Reddy
据估计，兔眼前房内游离二氧化碳和碳酸氢根离子(总二氧化碳)的周转率约为每分钟4%。在计算时考虑了碳酸氢盐体系中几种成分的单独周转率，但没有考虑二氧化碳转化为碳酸氢根离子可能对周转率的加速作用。此外，该速率的计算值还取决于以下假设的有效性：给予乙酰唑胺(Diamox)前后房水和血浆之间的pH差保持不变，药物对二氧化碳或重碳酸盐离子的扩散速度没有影响，并且房水的流速被乙酰唑胺降低到一半。由于这些假设可能不准确，因此周转率的值必须视为近似值。不幸的是，前房翻转率的估算方法不适用于后房翻转率的估算，但使用铜标记的碳酸氢盐进行的初步实验确实表明，与其他物质相比，该速率非常快。人们认为，对总二氧化碳周转率进行更详细的研究将有助于更深入地了解房水产生的一些基本过程，并可能更好地理解眼压是如何维持和控制的。此外，已知乙酰唑胺和相关化合物影响水动力学系统的参数，其结果是降低眼压和减少房水中二氧化碳的浓度。Accordii‘i似乎值得研究总二氧化碳的周转，不仅在正常动物中，而且在那些使用这种方法的动物中也是如此
The rate of turnover of free carbon dioxide and bicarbonate ion (total carbon dioxide) in the anterior chamber of the eye of the rabbit has been estimated to be about 4% per minute.1 The separate rates of turnover of the several components of the bicarbonate system were taken into account in making the calculation, but no allowance was made for the possible accelerating effect on the turnover due to the conversion of carbon dioxide to bicarbonate ion. Moreover, the calculated value for the rate also depended upon the validity of the assumption that the difference in the pH between the aqueous humor and plasma before and after giving acetazolamide (Diamox) remained constant, that the drug had no effect on the rate of diffusion of either carbon dioxide or bicarbonate ion, and that the flow rate of aqueous humor was reduced to one-half by the acetazolamide. Since these assumptions may not be exact, the value for the turnover rate must be regarded as an approximation. Unfortunately, the method employed for estimating the turnover in the anterior chamber was not applicable for the estimation of the turnover in the posterior chamber, but preliminary experiments employing bicarbonate labeled with Cu did indicate that the* rate was very rapid compared with other substances. It was thought that a more detailed study of the turnover of total C02 would lead to greater insight into some of the fundame tal processes involved in the production aqueous humor as a whole and possibly a' to a better understanding of how w intraocular pressure is maintained and ^ trolled. Furthermore, it is known that aC azolamide and related compounds affect <" of the parameters of the system of aqueO" humor dynamics, a consequence of which the lowering of intraocular pressure and reduction in the concentration of the W CO2 in the aqueous humors. Accordii'i it seemed worth while to investigate ^ turnover of total CO2 not only in nor11 animals but also in those given this dn* Methods