Cut-off points of the visceral adiposity index (VAI) identifying a visceral adipose dysfunction associated with cardiometabolic risk in a Caucasian Sicilian population.
Cut-off points of the visceral adiposity index (VAI) identifying a visceral adipose dysfunction associated with cardiometabolic risk in a Caucasian Sicilian population.
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DOI：
10.1186/1476-511x-10-183
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发表时间：
2011-10-19
影响因子：
4.5
通讯作者：
Galluzzo A
中科院分区：
文献类型：
--
作者：
Amato MC;Giordano C;Pitrone M;Galluzzo A
内脏脂肪指数（VAI）是一个针对性别的数学指数，基于腰围（WC）、体重指数（BMI）、甘油三酯（TG）和高密度脂蛋白胆固醇（HDL）水平，间接表达内脏脂肪功能和胰岛素敏感性。我们的目的是找到 VAI 的最佳切点，以识别西西里高加索人群中与心脏代谢风险相关的内脏脂肪功能障碍 (VAD)。使用接受者操作特征 (ROC) 曲线对 1,764 名初级保健患者 (PC 患者) 的体检数据进行回顾性横断面检查，以确定适当的 VAI 年龄分层截止值，以便根据 NCEP-ATP III 标准识别患有代谢综合征 (MetS) 的 PC 患者。根据VAI三分位数将VAI评分较高的PC患者分为三组（即轻度VAD、中度VAD或重度VAD的PC患者）。最后，将 VAD 类别与经典心脑血管危险因素进行比较，作为冠心病和/或心肌梗死、短暂性脑缺血发作和/或缺血性中风的独立预测因子。中度和重度 VAD 被证明与心血管事件独立相关[分别为（OR：5.35；95% CI：1.92-14.87；p = 0.001）和（OR：7.46；95% CI：2.64-21.05；p < 0.001）]。轻度、中度和重度 VAD 被发现与脑血管事件独立相关 [(OR: 2.73; 95% CI: 1.12-6.65; p = 0.027), (OR: 4.20; 95% CI: 1.86-9.45; p = 0.001) 和 (OR: 5.10; 95% CI: 2.14-12.17；p < 0.001）分别]。我们的研究表明，在西西里高加索受试者中，存在明确的 VAI 临界点，能够识别与心脏代谢风险密切相关的 VAD。
The Visceral Adiposity Index (VAI) is a sex-specific mathematical index, based on Waist Circumference (WC), Body Mass Index (BMI), triglycerides (TG) and HDL cholesterol (HDL) levels, indirectly expressing visceral adipose function and insulin sensitivity. Our aim was to find the optimal cut-off points of VAI identifying a visceral adipose dysfunction (VAD) associated with cardiometabolic risk in a Caucasian Sicilian population. Medical check-up data of 1,764 Primary Care patients (PC patients) were retrospectively and cross-sectionally examined using a receiver-operating characteristic (ROC) curve to determine appropriate stratified-for-age cut-off of VAI, for the identification of PC patients with Metabolic Syndrome (MetS) according to the NCEP-ATP III criteria. The PC patients with higher VAI scores were subdivided into three groups according to VAI tertiles (i.e. PC patients with mild VAD, moderate VAD or severe VAD). Finally, VAD classes were compared to classical cardio- and cerebrovascular risk factors as independent predictors of coronary heart disease and/or myocardial infarction, transient ischemic attack and/or ischemic stroke. Moderate and severe VADs proved to be independently associated with cardiovascular events [(OR: 5.35; 95% CI: 1.92-14.87; p = 0.001) and (OR: 7.46; 95% CI: 2.64-21.05; p < 0.001) respectively]. Mild, moderate and severe VADs were found to be independently associated with cerebrovascular events [(OR: 2.73; 95% CI: 1.12-6.65; p = 0.027), (OR: 4.20; 95% CI: 1.86-9.45; p = 0.001) and (OR: 5.10; 95% CI: 2.14-12.17; p < 0.001) respectively]. Our study suggests that among Caucasian Sicilian subjects there are clear cut-off points of VAI able to identify a VAD strongly associated with cardiometabolic risk.