Serum neurofilament light levels correlate with change of olfactory function in multiple sclerosis
Serum neurofilament light levels correlate with change of olfactory function in multiple sclerosis
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DOI：
10.1177/2055217319885987
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发表时间：
2019-10-01
影响因子：
2.8
通讯作者：
Berger, Thomas
中科院分区：
文献类型：
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作者：
Bsteh, Gabriel;Berek, Klaus;Berger, Thomas
背景：血清神经丝轻链水平（sNfL）和嗅觉功能受损是多发性硬化（MS）的生物标志物。目的：探讨sNfL水平与MS患者嗅觉功能的关系。方法：我们每年检测sNfL水平和嗅觉功能（Sniffin' Sticks测试：阈值（T）和联合辨别-识别（DI）评分），并将sNfL与T和DI评分进行比较。T评分与同时测量的sNfL水平显著相关（-1.5分，95%CI：每10 pg/ml sNfL增加-2.6-0.5; p= 2高于第75百分位数的sNfL测量值显示与没有或只有一个高于第75百分位数的sNfL测量值的患者相比，DI降低显著更大（中位数3.0分，IQR 2.0-4.5）（0.0，IQR -0.5-0.5，p
Background: Serum neurofilament light chain levels (sNfL) and impairment of olfactory function emerge as biomarkers in multiple sclerosis (MS). However, the relation between sNfL and olfactory function in MS has not been investigated yet.Objective: We aimed to determine whether sNfL levels correlate with olfactory function in relapsing-remitting (RR) MS.Methods: We annually measured sNfL and olfactory function (Sniffin' Sticks test: Threshold (T) and combined discrimination-identification (DI) score) in 80 RRMS patients and compared sNfL to T and DI scores.Results: T scores significantly correlated with sNfL levels at simultaneous measurement (-1.5 points, 95% CI: -2.6-0.5 per 10 pg/ml sNfL increase; p= 2 sNfL measures above the 75th percentile displayed significantly larger DI decrease (median 3.0 points, IQR 2.0-4.5) compared to patients with no or only one sNfL measure above the 75th percentile (0.0, IQR -0.5-0.5, p