Processing of sensory signals by a non-spiking neuron in the leech
Processing of sensory signals by a non-spiking neuron in the leech
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水蛭中的非尖峰神经元处理感觉信号
DOI：
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发表时间：
2000
期刊：
影响因子：
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通讯作者：
L. Szczupak
中科院分区：
文献类型：
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作者：
A. Marin;L. Szczupak
抽象的。非尖峰神经元151作为双侧对存在于水蛭神经系统的每个中体神经节中，并且它们电耦合到若干运动神经元。细胞内记录被用来研究这些神经元如何处理来自孤立神经节中的机械感觉P神经元的输入。在单个P细胞中诱导锋电位序列（15 Hz）诱发了细胞151中去极化和超极化相结合的反应。通过尖峰中间神经元传输的相位去极化在约-20 mV处逆转。超极化有两个成分，都在-65 mV左右逆转，并被士的宁（10 µmol l-1）抑制。较快的成分通过尖峰中间神经元传递，较慢的成分通过直接的P-151相互作用传递。短（<400 ms）的P细胞峰电位（15 Hz）诱发叠加在超极化上的阶段性去极化，而长（>500 ms）的P细胞峰电位产生一系列的去极化，掩盖了超极化相。超极化的幅度和持续时间在刺激串的初始尖峰处达到最大值，而去极化在整个刺激串的持续时间内持续存在。反应的两个阶段相对不受尖峰频率（5-25 Hz）的影响。非尖峰发放神经元151在时间域而不是幅度域中处理感觉信号。
Abstract. The non-spiking neurons 151 are present as bilateral pairs in each midbody ganglion of the leech nervous system and they are electrically coupled to several motorneurons. Intracellular recordings were used to investigate how these neurons process input from the mechanosensory P neurons in isolated ganglia. Induction of spike trains (15 Hz) in single P cells evoked responses that combined depolarizing and hyperpolarizing phases in cells 151. The phasic depolarizations, transmitted through spiking interneurons, reversed at around –20 mV. The hyperpolarization had two components, both reversing at around –65 mV, and which were inhibited by strychnine (10 µmol l–1). The faster component was transmitted through spiking interneurons and the slower component through a direct P-151 interaction. Short trains (<400 ms) of P cell spikes (15 Hz) evoked the phasic depolarizations superimposed on the hyperpolarization, while long spike trains (>500 ms) produced a succession of depolarizations that masked the hyperpolarizing phase. The amplitude and duration of the hyperpolarization reached their maximum at the initial spikes in a train, while the depolarizations persisted throughout the duration of the stimulus train. Both phases of the response were relatively unaffected by the spike frequency (5–25 Hz). The non-spiking neurons 151 processed the sensory signals in the temporal rather than in the amplitude domain.