Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1.
Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1.
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发表时间：
1995-11
期刊：
影响因子：
11.2
通讯作者：
Stephen M. Hewitt;Shinshichi Hamada;Timothy J. McDonnell;F. Rauscher;Grady F. Saunders
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文献类型：
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作者：
Stephen M. Hewitt;Shinshichi Hamada;Timothy J. McDonnell;F. Rauscher;Grady F. Saunders
Wilms肿瘤基因WT1作为肿瘤抑制基因，可抑制多种生长因子和生长因子受体的转录。bcl-2和c-myc原癌基因对细胞凋亡和细胞增殖的调控至关重要，在细胞发育和肿瘤发生中起作用。我们发现WT1可以抑制bcl-2和c-myc启动子的转录。这表明WT1在肾脏发育过程中调节bcl-2和c-myc，功能WT1的缺失导致bcl-2和c-myc的失调，从而促进肿瘤的形成。
The Wilms' tumor gene WT1 functions as a tumor suppressor gene, repressing transcription of several growth factors and growth factor receptors. The bcl-2 and c-myc proto-oncogenes are essential for regulation of apoptosis and cell proliferation with roles in development and oncogenesis. We found that WT1 can repress transcription of both the bcl-2 and c-myc promoters. This suggests that WT1 regulates bcl-2 and c-myc during renal development, and the loss of functional WT1 results in deregulation of bcl-2 and c-myc, contributing to tumor formation.