Finite element analysis of pharmaceutical tablet compaction using a density dependent material plasticity model
Finite element analysis of pharmaceutical tablet compaction using a density dependent material plasticity model
复制标题
DOI：
10.1016/j.powtec.2010.04.001
复制
发表时间：
2010-08
影响因子：
5.2
通讯作者：
Tuhin Sinha;R. Bharadwaj;J. Curtis;Bruno C. Hancock;C. Wassgren
中科院分区：
文献类型：
--
作者：
Tuhin Sinha;R. Bharadwaj;J. Curtis;Bruno C. Hancock;C. Wassgren
采用Drucker-Prager Cap（DPC）模型对药物片剂的压制过程进行了有限元模拟，其中材料的相对密度（固相分数）与材料的性能有关。从固相分数依赖模型的结果进行了比较，从一个恒定的属性模型。从固体分数依赖模型的预测更紧密地匹配实验测量的表面硬度，冲压力，和材料位移比恒定的属性模型。这些结果表明，使用DPC模型的有限元模拟应考虑材料性能对局部固相分数的依赖性。
Finite element method (FEM) simulations of pharmaceutical tablet compaction using a Drucker–Prager Cap (DPC) model are presented in which material properties are relative density (solid fraction) dependent. Results from the solid fraction dependent model are compared to those from a constant property model. Predictions from the solid fraction dependent model more closely match experimental measurements of surface hardness, punch force, and material displacement than the constant property model. These results suggest that FEM simulations using the DPC model should account for material property dependence on local solid fraction.