Catalytic Enantioselective 1,3-Dipolar Cycloaddition of C,N-Cyclic Azomethine Imines with α,β-Unsaturated Aldehydes
Catalytic Enantioselective 1,3-Dipolar Cycloaddition of C,N-Cyclic Azomethine Imines with α,β-Unsaturated Aldehydes
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DOI：
10.1021/ja100787a
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发表时间：
2010-03-31
影响因子：
15
通讯作者：
Maruoka, Keiji
中科院分区：
文献类型：
--
作者：
Hashimoto, Takuya;Maeda, Yuko;Maruoka, Keiji
一类尚未开发的偶氮甲碱亚胺，即 C,N-环状偶氮甲碱亚胺，可以成功地用于与二元醇钛催化的烯醛进行高度对映选择性的 1,3-偶极环加成反应，得到具有药物吸引力的四氢异喹啉和哌啶基序。
A yet-unexploited class of azomethine imines, C,N-cyclic azomethine imines, could be successfully employed in highly enantioselective 1,3-dipolar cycloaddition with enals catalyzed by titanium-BINOLate to give pharmaceutically attractive tetrahydroisoquinoline and piperidine motifs.