MACROPHAGE RESPONSES IN INFLAMMATORY DEMYELINATING NEUROPATHIES
MACROPHAGE RESPONSES IN INFLAMMATORY DEMYELINATING NEUROPATHIES
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DOI：
10.1002/ana.410270717
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发表时间：
1990-01-01
影响因子：
11.2
通讯作者：
CORNBLATH, DR
中科院分区：
文献类型：
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作者：
GRIFFIN, JW;STOLL, G;CORNBLATH, DR
巨噬细胞是炎性脱髓鞘性神经病的主要参与者。为了提供一种不同的方法来评价巨噬细胞的行为，我们使用了被梳理的神经纤维和神经内膜血管的免疫染色。我们评估了巨噬细胞在炎性脱髓鞘性神经病变中的出现频率，它们与正常和脱髓鞘纤维的关系，以及它们的主要组织相容性II类标志物（Ia抗原）的表达。在6例慢性炎性神经病患者和1例格林-巴利综合征患者中，我们发现巨噬细胞经常粘附在受损的血管上。假定进入神经的细胞被拉长，通常具有极化外观，表明运动性，并且是Ia阳性。进入神经后，Ia阳性巨噬细胞粘附于正常和脱髓鞘纤维。在穿透神经纤维并去除髓鞘后，它们通常保留Ia阳性。判断为吞噬后的泡沫状巨噬细胞为Ia阴性。粘附在血管上的泡沫状巨噬细胞被认为是离开神经的。将这种作为Ia阳性前吞噬细胞进入并演变为Ia阴性泡沫巨噬细胞的模式与其他实验和人类神经病变进行了比较。
Macrophages are prominent participants in inflammatory demyelinating neuropathies. To provide a different means of evaluating macrophage behavior, we used immunostaining of teased nerve fibers and endoneurial blood vessels. We assessed the frequency with which macrophages were seen in inflammatory demyelinating neuropathies, their relationship to normal and demyelinating fibers, and their expression of major histocompatibility Class II markers (Ia antigen). In 6 patients with chronic inflammatory neuropathy and 1 with Guillain‐Barré syndrome, we found regularly that macrophages were adherent to teased blood vessels. Cells presumed to be entering the nerve were elongated, often with a polarized appearance suggesting motility, and were Ia‐positive. After entry into nerve, the Ia‐positive macrophages were adherent to both normal and demyelinating fibers. They often retained their Ia positivity after penetrating into the nerve fiber and removing myelin. Foamy macrophages, judged to be postphagocytic, were Ia‐negative. The foamy macrophages found adhering to blood vessels were presumed to be leaving the nerve. This pattern of entry as Ia‐positive prephagocytic cells and evolution to Ia‐negative foamy macrophages was compared with other experimental and human neuropathies.