ASTROCYTES - AUXILIARY CELLS FOR IMMUNE-RESPONSES IN THE CENTRAL-NERVOUS-SYSTEM
ASTROCYTES - AUXILIARY CELLS FOR IMMUNE-RESPONSES IN THE CENTRAL-NERVOUS-SYSTEM
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DOI：
10.1016/0167-5699(90)90106-j
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发表时间：
1990-08-01
期刊：
影响因子：
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通讯作者：
WAKSMAN, BH
中科院分区：
文献类型：
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作者：
HERTZ, L;MCFARLIN, DE;WAKSMAN, BH
活跃和复制的星形胶质细胞在多发性硬化（MS）病变和类似MS的实验性脱髓鞘疾病中很突出。随着证据的积累，支持MS的自身免疫病因学，星形胶质细胞作为辅助/效应细胞在组织损伤和随后的瘢痕形成中的可能贡献引起了相当大的关注。最近的一次研讨会促进了对星形胶质细胞感兴趣的神经生物学家和对脱髓鞘疾病感兴趣的研究人员之间的互动。关键问题是试图将脱髓鞘病变中星形胶质细胞的行为与体外模型系统中的发现联系起来，以区分各种星形胶质细胞功能（辅助，效应，瘢痕形成）并确定与每种功能相关的调节机制。
Active and replicating astrocytes are prominent in multiple sclerosis (MS) lesions and in experimental demyelinating diseases resembling MS. As evidence is amassed supporting an autoimmune etiology for MS, the possible contribution of astrocytes as auxiliary/effector cells in the generation of tissue damage and subsequent scar formation has attracted considerable attention. A recent workshop fostered interaction between neurobiologists interested in astrocytes and investigators interested in demyelinative diseases. Key issues were attempts to relate the behavior of astrocytes in demyelinative lesions to findings in model systems in vitro, to distinguish various astrocyte functions (auxiliary, effector, scar formation) and to identify the regulatory mechanisms associated with each function.