An exploratory approach to the serotonergic hypothesis of depression: bridging the synaptic gap
An exploratory approach to the serotonergic hypothesis of depression: bridging the synaptic gap
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DOI：
10.1054/mehy.2000.1187
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发表时间：
2001-02-01
影响因子：
4.7
通讯作者：
Kutcher, SP
中科院分区：
文献类型：
--
作者：
Dursun, SM;Blackburn, JR;Kutcher, SP
在这篇探索性综述中，我们尝试整合抑郁症生化基础的突触前和突触后理论，特别是关于 5-HT 的理论。我们将提供证据表明，在重度抑郁症中，神经功能存在连续性功能障碍，即突触前和突触后血清素能症状受到影响。此外，我们还将提供这种方法对抑郁症正常治疗的影响。 (C) 2001 年哈考特出版有限公司。
In this exploratory review, we attempt to integrate pre and post synaptic theories of the biochemical basis of depression-in particular with regard to 5-HT. We will be providing evidence that in major depressive disorder, there is a continuity of dysfunction of neural function, i.e. pre and post synaptic serotonergic symptoms are affected. Furthermore, we will also be providing the implications of this approach for normal treatments for depressive disorder. (C) 2001 Harcourt Publishers Ltd.