Prediabetes, elevated iron and all-cause mortality: a cohort study.
Prediabetes, elevated iron and all-cause mortality: a cohort study.
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DOI：
10.1136/bmjopen-2014-006491
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发表时间：
2014-12-11
期刊：
影响因子：
2.9
通讯作者：
Baker R
中科院分区：
文献类型：
--
作者：
Mainous AG 3rd;Tanner RJ;Coates TD;Baker R
数据表明，患有前驱糖尿病的个体的死亡风险低至不存在增加，但尚不清楚当患者铁标志物升高时，风险是否会增加。我们的目的是研究在同时存在转铁蛋白饱和度（TS）或血清铁蛋白升高的情况下，糖尿病前期成人患者的死亡风险。美国第三次国家健康与营养检查调查1988-1994年（NHANES III）和国家卫生统计中心1988年至2006年国家死亡指数收集的数据。参加NHANES并提供血液样本的40岁及以上的个人。死亡率以全因死亡率衡量。校正后的分析显示，糖尿病前期的死亡风险略有增加（HR=1.04; 95% CI 1.00 - 1.08）。与铁蛋白正常和血糖正常的人相比，糖尿病前期和血清铁蛋白升高的人死亡HR增加（HR=1.14; 95%CI 1.04至1.24）。在TS升高的糖尿病前期患者中，与TS水平正常且血糖正常的患者相比，其死亡风险增加（HR=1.88; 95%CI 1.06 - 3.30）。糖尿病前期的死亡风险很低。然而，在同时存在铁标记物升高的个体中，特别是TS，风险大幅上升。
Data have indicated low to non-existent increased mortality risk for individuals with prediabetes, but it is unclear if the risk is increased when the patient has elevated iron markers. Our purpose was to examine the mortality risk among adults with prediabetes in the context of coexisting elevated transferrin saturation (TS) or serum ferritin. Data collected by the third National Health and Nutrition Examination Survey 1988–1994 (NHANES III) in the USA and by the National Center for Health Statistics for the National Death Index from 1988 to 2006. Individuals age 40 and older who participated in the NHANES and provided a blood sample. Mortality was measured as all-cause mortality. Adjusted analyses show that prediabetes has a small increased mortality risk (HR=1.04; 95% CI 1.00 to 1.08). Persons who had prediabetes and elevated serum ferritin had an increased HR for death (HR=1.14; 95% CI 1.04 to 1.24) compared with those who had normal ferritin and normal glucose. Among persons with prediabetes who had elevated TS, they had an increased mortality risk (HR=1.88; 95% CI 1.06 to 3.30) compared with those with normal TS levels and normal glucose. The mortality risk of prediabetes is low. However, among individuals who have coexisting elevated iron markers, particularly TS, the risk rises substantially.
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影响因子：
16.2
作者：
American Diabetes Association
通讯作者：
American Diabetes Association
血红蛋白A1C和禁食等离子体葡萄糖定义的美国前糖尿病前期的世俗变化：国家健康和营养检查调查，1999-2010。
影响因子：
16.2
作者：
Bullard KM;Saydah SH;Imperatore G;Cowie CC;Gregg EW;Geiss LS;Cheng YJ;Rolka DB;Williams DE;Caspersen CJ
通讯作者：
Caspersen CJ
影响因子：
3.5
作者：
Deedwania, Prakash;Patel, Kanan;Ahmed, Ali
通讯作者：
Ahmed, Ali
影响因子：
7.7
作者：
Fernández-Real, JM;Peñarroja, G;Ricart, W
通讯作者：
Ricart, W
影响因子：
37.8
作者：
Pearson, TA;Mensah, GA;Vinicor, F
通讯作者：
Vinicor, F