Limitation and facilitation in the vectors and other aspects of the dynamics of filarial transmission:: the need for vector control against Anopheles-transmitted filariasis
Limitation and facilitation in the vectors and other aspects of the dynamics of filarial transmission:: the need for vector control against Anopheles-transmitted filariasis
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DOI：
10.1179/000349802125002509
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发表时间：
2002-12-01
影响因子：
--
通讯作者：
Pichon, G
中科院分区：
文献类型：
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作者：
Pichon, G
在某些丝虫-蚊子组合中，在蚊子中发育的感染性第三阶段幼虫（L-3）的数量与该蚊子摄入的微丝蚴（mff）的数量不成比例。随着摄入的mff数量增加，每个微丝蚴的L3产量可能增加（在称为“促进”的过程中）或减少（在称为“限制”的过程中）。每一个成功摄入的微丝蚴（就到达血腔而言）都会增加（促进）或减少（限制）下一个微丝蚴对胃壁的“渗透性”。在一些库蚊中观察到限制，特别是伊蚊属。其传播班氏吴策线虫，因此，由于它们摄取较少的MFF，因此作为载体变得相对更有效。这一现象使得阻断伊蚊传播丝虫成为可能。由于按蚊的生存受到丝虫感染的不利影响，使用大规模药物施用（MDA）来降低微丝蚴血症的流行率和强度可以增加一些当地按蚊物种的平均寿命。如果这些相同的物种也作为疟疾寄生虫的载体，有效的，基于药物的控制W。bancrofti可能会使疟疾带来的问题恶化。因此，在疟疾和班氏丝虫病共同流行并由同种蚊子传播的寄生虫引起的地方，应通过对成年按蚊的干预措施（使用蚊帐或室内喷洒）来加强MDA。
In certain filaria-mosquito combinations, the number of infective, third-stage larvae (L-3) that develop in a mosquito is not proportional to the number of microfilariae (mff) ingested by that mosquito. As the number of mff ingested increases, the yield of L3 per microfilaria may either increase (in a process known as 'facilitation') or decrease (in a process known as 'limitation'). Each ingested microfilaria that is successful (in terms of reaching the haemocoel) increases (facilitation) or decreases (limitation) the 'permeability' of the stomach wall for the next microfilaria. Limitation is seen in some culicine mosquitoes, especially the Aedes spp. that transmit Wuchereria bancrofti, which, in consequence, become relatively more efficient as vectors as they ingest fewer mff. This phenomenon makes the interruption of filarial transmission by Aedes spp. particularly difficult.As the survival of anopheline mosquitoes is adversely affected by filarial infection, the use of mass drug administrations (MDA) to reduce the prevalence and intensity of microfilaraemias may increase the mean life-span of some of the local Anopheles species. If these same species also act as vectors of malarial parasites, effective, drug-based control of W. bancrofti may worsen the problem posed by malaria. Therefore, wherever malaria and bancroftian filariasis are co-endemic and caused by parasites transmitted by the same species of mosquito, MDA should be augmented by interventions (use of bednets or house-spraying) against adult Anopheles.