Short Delay in Initiation of Radiotherapy May Not Affect Outcome of Patients With Glioblastoma: A Secondary Analysis From the Radiation Therapy Oncology Group Database
Short Delay in Initiation of Radiotherapy May Not Affect Outcome of Patients With Glioblastoma: A Secondary Analysis From the Radiation Therapy Oncology Group Database
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DOI：
10.1200/jco.2008.18.9035
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发表时间：
2009-02-10
影响因子：
45.3
通讯作者：
Corn, Benjamin W.
中科院分区：
文献类型：
--
作者：
Blumenthal, Deborah T.;Won, Minhee;Corn, Benjamin W.
PurposeTo分析放射治疗肿瘤组（RTOG）数据库的胶质母细胞瘤患者和评价结果是否受到影响的时间开始放射治疗（RT）。患者和MethodsFrom 1974年至2003年，成人患者与组织学证实幕上胶质母细胞瘤被纳入16 RTOG研究。在3，052例入组患者中，197例患者（6%）最初不合格或时间顺序数据不足，留下2，855例患者进行本分析。我们根据从手术到RT开始的时间间隔选择了四个患者组：4周），而不是延迟时间最短的患者组（
PurposeTo analyze the Radiation Therapy Oncology Group (RTOG) database of patients with glioblastoma and appraise whether outcome was influenced by time to initiation of radiation therapy (RT).Patients and MethodsFrom 1974 through 2003, adult patients with histologically confirmed supratentorial glioblastoma were enrolled onto 16 RTOG studies. Of 3,052 enrolled patients, 197 patients (6%) were either initially rendered ineligible or had insufficient chronologic data, leaving a cohort of 2,855 patients for the present analysis. We selected four patient groups based on the interval from surgery to the start of RT: 4 weeks) than in those with the shortest delay (