Regulation of body size in Caenorhabditis elegans: effects of environmental factors and the nervous system.
Regulation of body size in Caenorhabditis elegans: effects of environmental factors and the nervous system.
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DOI：
10.1387/ijdb.160352ss
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发表时间：
2017-07
期刊：
影响因子：
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通讯作者：
T. Nagashima;S. Ishiura;S. Suo
中科院分区：
文献类型：
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作者：
T. Nagashima;S. Ishiura;S. Suo
身体大小是动物的基本特征之一，并被调节以适应环境。动物通过感觉神经元感知环境刺激，来自神经系统的信号改变器官的大小，从而调节身体大小。模式动物秀丽隐杆线虫特别适合于体型调节的遗传分析，并且已经为阐明调节体型的各种遗传途径做出了贡献。在这篇综述中，我们总结了现有的文献有关的环境因素，调节身体的大小和神经系统在这种调节中的作用。我们详细讨论了最近的一份关于神经递质多巴胺调节体型的报告。
Body size is one of the basic traits of animals and is regulated to adapt to the environment. Animals perceive environmental stimuli with sensory neurons, and signals from the nervous system alter the size of organs, thus regulating body size. The model animal Caenorhabditis elegans is particularly suited for genetic analysis of body size regulation, and has already contributed to the elucidation of various genetic pathways that regulate body size. In this review, we summarize the available literature regarding environmental factors that regulate body size and the role of the nervous system in such regulation. We discuss in detail a recent report on body size regulation by the neurotransmitter, dopamine.