Cocaine does not compromise cerebral or myocardial oxygen delivery in fetal sheep.
Cocaine does not compromise cerebral or myocardial oxygen delivery in fetal sheep.
复制标题
可卡因不会影响胎羊的脑或心肌氧输送。
DOI：
10.1071/rd9960383
复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Phillips,D
中科院分区：
文献类型：
--
作者：
Burchfield,DJ;Peña,A;Peters,AJ;Abrams,RM;Phillips,D
Eight time-dated pregnant ewes at 125 days' gestation (145 days = term) underwent surgery for placement of fetal vascular catheters, electrodes for recording fetal behavioural state, and maternal venous catheters. Three days later, fetal cerebral and myocardial blood flow were determined by the coloured microsphere technique under four conditions: (1) during rapid-eye movement (REM) sleep, before fetal cocaine infusion, (2) 30 min after initiation of a cocaine infusion to the fetus at 0.2 mg/kg per min, (3) during REM sleep, before maternal cocaine infusion, and (4) 30 min after initiation of a cocaine infusion to the ewe at 0.3 mg/kg per min. Cocaine infusion directly to the fetal lamb did not cause hypoxaemia or significantly change cerebral or myocardial blood flow or oxygen delivery. Cocaine administered to the ewe led to a drop in fetal oxygen tension from 3.0 +/- 0.5 to 2.5 +/- 0.3 kPa (P < 0.0001) and in fetal oxygen content from 3.8 +/- 0.7 to 2.8 +/- 0.4 mmol O2/L (P < 0.0001). Prior to maternal cocaine administration, fetal cerebral blood flow was 146 +/- 103 mL/100 g per min and during maternal cocaine infusion it went to 184 +/- 147 mL/100 g per min (P = NS) while myocardial blood flow increased from 156 +/- 92 to 333 +/- 178 mL/100 g per min (P < 0.002). This increase in blood flow negated the effects of hypoxaemia so that cerebral oxygen delivery was unaffected while myocardial oxygen delivery increased an average of 67%. It is concluded that cocaine administration to pregnant sheep does not impede fetal cerebral or myocardial oxygen delivery.
登录
查看更多内容
胎羔的大脑氧化代谢：与皮层电状态的关系。
影响因子：
9.8
作者：
B. Richardson;B. Richardson;J. Patrick;J. Patrick;H. Abduljabbar;H. Abduljabbar
通讯作者：
H. Abduljabbar
可卡因对猫软脑膜小动脉的影响。
影响因子：
8.3
作者：
Shuji Dohi;M. D. Jones;Mark L. Hudak;R. Traystman
通讯作者：
R. Traystman
新生儿胎便中可卡因的分析。
影响因子：
4.1
作者：
S. Browne;I. Tebbett;C. Moore;A. Dusick;R. Covert;G. T. Yee
通讯作者：
G. T. Yee
可卡因对胎羊皮层电活动的影响。
DOI：
10.1016/0165-3806(92)90107-8
发表时间：
1992
期刊：
Brain research. Developmental brain research
影响因子：
--
作者：
Abrams,RM;Burchfield,DJ;Gerhardt,KJ;Peters,AJ
通讯作者：
Peters,AJ
可卡因会改变胎羊的行为状态。
DOI：
10.1016/0165-3806(90)90162-r
发表时间：
1990
期刊：
Brain research. Developmental brain research
影响因子：
--
作者：
Burchfield,DJ;Graham,EM;Abrams,RM;Gerhardt,KJ
通讯作者：
Gerhardt,KJ