Differences between echocardiographic measurements of left ventricular dimensions and function by local investigators and a core laboratory in a 2-year follow-up study of patients with an acute myocardial infarction.
Differences between echocardiographic measurements of left ventricular dimensions and function by local investigators and a core laboratory in a 2-year follow-up study of patients with an acute myocardial infarction.
复制标题
当地研究人员和核心实验室在对急性心肌梗死患者进行的 2 年随访研究中，超声心动图测量的左心室尺寸和功能之间的差异。
DOI：
10.1053/euje.3.4.263
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
T. Skjærpe
中科院分区：
文献类型：
--
作者：
T. Hole;J. Otterstad;M. S. Sutton;G. Frøland;I. Holme;T. Skjærpe
目标管理系统
在多中心系列超声心动图研究中，检查当地研究人员和核心实验室之间左心室尺寸和功能测量值以及预后价值的差异。
方法和结果
对 756 名患有急性心肌梗塞且左心室功能保留的患者进行了基线检查和 3 个月后的双翼辛普森法测量，并前瞻性随访 3 至 24 个月。在基线和 3 个月时，当地研究人员相对于核心实验室测量的舒张末期容积分别减少了 8 和 6 毫升（P<0.001），收缩末期容积分别减少了 3 和 2 毫升（P<0.01），射血分数分别减少了 0.0% 和 0.6%（P<0.01）。当地研究人员和核心实验室测得左心室舒张末期容积增加了 8.6 和 6.9 毫升，左心室收缩末期容积增加了 5.2 和 4.3 毫升，左心室射血分数减少了 0.6 和 0.0%。使用 Cox 比例风险模型，后续临床终点的预后价值对于核心实验室测量的 3 个月值 (P<0.05) 和变化 (P<0.005) 均显着，但当地研究人员测量的结果则不显着。
结论
只有核心实验室的测量结果对后续临床终点具有显着的预后价值。这些结果强烈支持在采用超声心动图测量的研究中使用核心实验室。
AIMS
To examine differences in measurements of left ventricular dimensions and function, and prognostic value between local investigators and a core laboratory in a multicentre serial echocardiographic study.
METHODS AND RESULTS
Seven hundred and fifty-six patients with acute myocardial infarction and preserved left ventricular function were examined at baseline and after 3 months with measurements by the biplane Simpson's method, and followed prospectively from 3 to 24 months. At baseline and 3 months local investigators relative to the core laboratory measured lesser end-diastolic volume by 8 and 6 ml (P<0.001), end-systolic volume by 3 and 2 ml (P<0.01), and ejection fraction by 0.0 and 0.6% (P<0.01), respectively. Local investigators and the core laboratory measured an increase in left ventricular end-diastolic volume of 8.6 and 6.9 ml, and in left ventricular end-systolic volume of 5.2 and 4.3 ml, and a decrease in left ventricular ejection fraction of 0.6 and 0.0%. Using the Cox proportionate hazards model, the prognostic value for subsequent clinical endpoints was significant both for the 3-month values (P<0.05) and changes (P<0.005) measured by the core laboratory, but not by local investigators.
CONCLUSION
Only measurements in the core laboratory had significant prognostic value for subsequent clinical endpoints. These results strongly support the use of a core laboratory in studies employing echocardiographic measurements.
DOI：
10.1016/s0735-1097(99)00551-3
发表时间：
2000-02-01
影响因子：
24
作者：
Chuang, ML;Hibberd, MG;Manning, WJ
通讯作者：
Manning, WJ