Association of frontal gray matter volume and cerebral perfusion in heroin addiction: a multimodal neuroimaging study.
Association of frontal gray matter volume and cerebral perfusion in heroin addiction: a multimodal neuroimaging study.
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DOI：
10.3389/fpsyt.2013.00135
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发表时间：
2013
影响因子：
4.7
通讯作者：
Borgwardt S
中科院分区：
文献类型：
--
作者：
Denier N;Schmidt A;Gerber H;Schmid O;Riecher-Rössler A;Wiesbeck GA;Huber CG;Lang UE;Radue EW;Walter M;Borgwardt S
健康人脑的结构和功能密切相关。在长期接触海洛因的患者中，脑成像研究已经确定了灰质（GM）体积的长期变化。最近，我们发现，急性应用海洛因依赖患者的结果与安慰剂条件相比，额颞区灌注不足。然而，海洛因成瘾的结构和脑血流量（CBF）的变化之间的关系还没有被调查。此外，尚不清楚慢性结构变化与海洛因对灌注的短期和长期影响之间是否存在任何相互作用。采用双盲、受试者内设计，对14例来自稳定海洛因辅助治疗方案的海洛因依赖患者给予海洛因或安慰剂（生理盐水），以观察急性短期效应。动脉自旋标记（ASL）用于计算两种治疗条件下的灌注定量图，而基于体素的形态测定（VBM）用于计算区域GM密度。VBM和ASL数据被用来计算同源相关领域的生物参数映射（BPM）和全脑皮尔逊r相关。我们将每种灌注条件（海洛因和安慰剂）分别与两种治疗条件相同的VBM样本相关联。假设海洛因相关灌注表现为短期效应，而安慰剂相关灌注与长期效应更相关。为了将我们的分析限制在额颞区，我们使用了显式掩码进行分析。相关性分析显示，GM和两种灌注条件（海洛因和安慰剂）之间的额叶区域显着正相关。海洛因相关的灌注也呈负相关，与GM在颞下回的两个半球。这些研究结果表明，在海洛因依赖患者中，低GM体积与额叶区域内的低灌注呈正相关。
Structure and function are closely related in the healthy human brain. In patients with chronic heroin exposure, brain imaging studies have identified long-lasting changes in gray matter (GM) volume. More recently, we showed that acute application of heroin in dependent patients results in hypoperfusion of fronto-temporal areas compared with the placebo condition. However, the relationship between structural and cerebral blood flow (CBF) changes in heroin addiction has not yet been investigated. Moreover, it is not known whether there is any interaction between the chronic structural changes and the short and long-term effects on perfusion caused by heroin. Using a double-blind, within-subject design, heroin or placebo (saline) was administered to 14 heroin-dependent patients from a stable heroin-assisted treatment program, in order to observe acute short-term effects. Arterial spin labeling (ASL) was used to calculate perfusion quantification maps in both treatment conditions, while Voxel-Based Morphometry (VBM) was conducted to calculate regional GM density. VBM and ASL data were used to calculate homologous correlation fields by Biological Parametric Mapping (BPM) and a whole-brain Pearson r correlation. We correlated each perfusion condition (heroin and placebo) separately with a VBM sample that was identical for the two treatment conditions. It was assumed that heroin-associated perfusion is manifested in short-term effects, while placebo-associated perfusion is more related to long-term effects. In order to restrict our analyses to fronto-temporal regions, we used an explicit mask for our analyses. Correlation analyses revealed a significant positive correlation in frontal areas between GM and both perfusion conditions (heroin and placebo). Heroin-associated perfusion was also negatively correlated with GM in the inferior temporal gyrus on both hemispheres. These findings indicate that, in heroin-dependent patients, low GM volume is positively associated with low perfusion within frontal regions.