beta-Lactam antibiotic inhibits development of morphine physical dependence in rats.
beta-Lactam antibiotic inhibits development of morphine physical dependence in rats.
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DOI：
10.1097/fbp.0b013e328337be10
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发表时间：
2010-03
影响因子：
1.6
通讯作者：
Kim J
中科院分区：
文献类型：
--
作者：
Rawls SM;Baron DA;Kim J
β-内酰胺抗生素增强细胞谷氨酸摄取。因为增加的吗啡能传递是阿片依赖的主要介质，我们测试了β-内酰胺抗生素（头孢曲松）防止大鼠吗啡身体依赖的发展的假设。吗啡（20 mg/kg）每天注射两次，共10 d，诱导身体依赖。最后一次注射吗啡后1、48和96 h给予纳洛酮（10 mg/kg）诱导戒断综合征，其特征为湿狗样抖动、牙齿抖动、眨眼、跳跃和爪震颤。在慢性吗啡暴露期间每天注射一次头孢曲松（150，200 mg/kg）可抑制每个纳洛酮诱发的戒断体征。头孢曲松疗效持续96小时纳洛酮（10 mg/kg）注射后。这些结果表明，β-内酰胺抗生素抑制导致吗啡身体依赖发展的过程。
β-lactam antibiotics enhance cellular glutamate uptake. Because increased glutamatergic transmission is a primary mediator of opiate dependence, we tested the hypothesis that a β-lactam antibiotic (ceftriaxone) prevents development of morphine physical dependence in rats. Morphine (20 mg/kg) was injected twice daily for 10 days to induce physical dependence. Naloxone (10 mg/kg) administration 1, 48 and 96 h after the last morphine injection induced a withdrawal syndrome characterized by the appearance of wet-dog shakes, teeth chattering, eye blinking, jumping, and paw tremor. Ceftriaxone (150, 200 mg/kg) injected once daily during chronic morphine exposure inhibited each naloxone-precipitated withdrawal sign. Ceftriaxone efficacy persisted even after the 96 h naloxone (10 mg/kg) injection. These results suggest β-lactam antibiotics inhibit processes leading to development of morphine physical dependence.