Influence of age upon ifosfamide-induced nephrotoxicity
Influence of age upon ifosfamide-induced nephrotoxicity
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DOI：
10.1002/pbc.20011
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发表时间：
2004-05-01
影响因子：
3.2
通讯作者：
Hawkins, DS
中科院分区：
文献类型：
--
作者：
McCune, JS;Friedman, DL;Hawkins, DS
背景资料。异环磷酰胺引起的肾毒性在儿童中得到很好的认识，尽管在成人中也有报道。目前尚不清楚异环磷酰胺肾毒性在儿童中是否比成人更常见。程序。对被诊断为肉瘤的成人和儿童接受异环磷酰胺累积剂量>；20g/m(2)的医疗记录进行了评估。确定了25名儿童(小于或等于18岁)和28名成年人。结果。国家癌症研究所共同毒性标准3-4级异环磷酰胺引起的肾毒性分别出现在24%的儿童和17%的成人中(P=0.58)。异环磷酰胺在两个人群中的累积剂量相似，儿童的中位数(范围)为70.2 g/m(2)(22.4-72)，成人的中位数(范围)为59 g/m(2)(20.8-146)(P=0.25)。Logistic回归分析显示，年龄和累积异环磷酰胺剂量与异环磷酰胺致3~4级肾毒性无关(P=0.36)。结论。接受异环磷酰胺20g/m(2)剂量的儿童和成人对异环磷酰胺引起的肾毒性的易感性相似。为了了解肾毒性的个体间差异，应该考虑年龄和累积剂量以外的因素。
Background. Ifosfamide-induced nephrotoxicity is well recognized in children, although it has also been reported in adults. Whether ifosfamide nephrotoxicity is more common in children than in adults is not known. Procedure. Medical records of adults and children diagnosed with sarcoma whom received ifosfamide with a cumulative dose >20 g/m(2) were evaluated. Twenty-five children (less than or equal to18-years of age) and 28 adults were identified. Results. National Cancer Institute Common Toxicity Criteria grade 3-4 ifosfamide-induced nephrotoxicity was present in 24 and 17% of children and adults, respectively (P=0.58). Cumulative ifosfamide doses were similar between the two populations, with the median (range) of 70.2 g/m(2) (22.4-72) for children and 59 g/m(2) (20.8-146) for adults (P=0.25). Logistic regression analysis indicated that neither age or cumulative ifosfamide dose were associated with grade 3-4 ifosfamide-induced nephrotoxicity (P=0.36). Conclusions. Children and adults receiving >20 g/m(2) of ifosfamide have similar susceptibility to ifosfamide-induced nephrotoxicity. Factors other than age and cumulative dose should be considered for understanding the inter-individual variation in nephrotoxicity.