MHC CLASS-I DEFICIENCY - SUSCEPTIBILITY TO NATURAL-KILLER (NK) CELLS AND IMPAIRED NK ACTIVITY
MHC CLASS-I DEFICIENCY - SUSCEPTIBILITY TO NATURAL-KILLER (NK) CELLS AND IMPAIRED NK ACTIVITY
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DOI：
10.1126/science.1853205
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发表时间：
1991-07-12
期刊：
影响因子：
56.9
通讯作者：
RAULET, D
中科院分区：
文献类型：
--
作者：
LIAO, NS;BIX, M;RAULET, D
主要组织相容性复合体 (MHC) I 类表达在自然杀伤 (NK) 细胞靶标识别中的作用存在争议。 研究发现，来自 MHC I 类缺陷突变小鼠的正常 T 细胞母细胞在体外可作为 NK 细胞的靶细胞，这表明 MHC I 类分子直接参与 NK 细胞识别。 突变小鼠的脾细胞缺乏裂解 MHC I 类缺陷靶细胞或 NK 敏感肿瘤靶标的能力，并且突变小鼠不能排斥同种异体骨髓。 因此，I类分子可能参与NK细胞的正选择或耐受诱导。
The role of major histocompatibility complex (MHC) class I expression in natural killer (NK) cell target recognition is controversial. Normal T cell blasts from MHC class I-deficient mutant mice were found to serve as target cells for NK cells in vitro, which suggests that MHC class I molecules are directly involved in NK cell recognition. Spleen cells from the mutant mice were deficient in their ability to lyse MHC class I-deficient target cells or NK-susceptible tumor targets, and mutant mice could not reject allogeneic bone marrow. Thus, class I molecules may participate in the positive selection or tolerance induction of NK cells.