Skin bioprinting: a novel approach for creating artificial skin from synthetic and natural building blocks.
Skin bioprinting: a novel approach for creating artificial skin from synthetic and natural building blocks.
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DOI：
10.1007/s40204-018-0087-0
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发表时间：
2018-06
影响因子：
4.9
通讯作者：
Augustine R
中科院分区：
文献类型：
--
作者：
Augustine R
在过去的几十年中，在模拟人类皮肤的体外工程替代品的开发方面取得了重大进展，无论是作为移植物用于替换丢失的皮肤，还是用于建立体外人类皮肤模型。组织工程是近年来在高分子工程、生物工程、干细胞研究和纳米医学等领域取得的新进展。最近，被称为生物打印的3D打印技术的进步被用来制造细胞负载支架，以生产与天然组织更匹配的构建体。生物打印促进了多种类型皮肤细胞和生物材料的同时和高度特异性沉积，这是传统皮肤组织工程方法所缺乏的过程。含有真皮和表皮成分的生物打印皮肤替代品或等同物为皮肤生物工程提供了一种有前途的方法。包括合成和天然生物聚合物以及具有或不具有信号分子如生长因子的细胞的各种材料正被用于产生功能性皮肤构造。该技术为克服目前皮肤组织工程中血管化不良、毛囊和汗腺缺失等瓶颈提供了一种新的策略。
Significant progress has been made over the past few decades in the development of in vitro-engineered substitutes that mimic human skin, either as grafts for the replacement of lost skin, or for the establishment of in vitro human skin models. Tissue engineering has been developing as a novel strategy by employing the recent advances in various fields such as polymer engineering, bioengineering, stem cell research and nanomedicine. Recently, an advancement of 3D printing technology referred as bioprinting was exploited to make cell loaded scaffolds to produce constructs which are more matching with the native tissue. Bioprinting facilitates the simultaneous and highly specific deposition of multiple types of skin cells and biomaterials, a process that is lacking in conventional skin tissue-engineering approaches. Bioprinted skin substitutes or equivalents containing dermal and epidermal components offer a promising approach in skin bioengineering. Various materials including synthetic and natural biopolymers and cells with or without signalling molecules like growth factors are being utilized to produce functional skin constructs. This technology emerging as a novel strategy to overcome the current bottle-necks in skin tissue engineering such as poor vascularization, absence of hair follicles and sweat glands in the construct.