Inhibition by biscoclaurine alkaloid of lipid peroxidation in biological membranes.
Inhibition by biscoclaurine alkaloid of lipid peroxidation in biological membranes.
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Biscoclaurine 生物碱对生物膜中脂质过氧化的抑制。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
K. Utsumi
中科院分区：
文献类型：
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作者：
N. Shiraishi;T. Arima;K. Aono;B. Inouye;Y. Morimoto;K. Utsumi
检查了双月桂碱型生物碱作为膜稳定剂的能力以及防止脂质过氧化和生物膜恶化的能力。得到以下结果。 Biscoclaurine 型生物碱抑制 Fe2+ 诱导的生物膜脂质过氧化。 Cepharanthine 可防止因 Fe2+ 诱导的脂质过氧化而导致的膜分隔减少。膜脂的过氧化会导致膜流动性降低，但千金藤碱可以防止这种降低。这些保护措施是特定于结构的。它们也是双高月桂碱型特异性的，不适用于双高月桂碱型生物碱，例如罂粟碱。基于这些发现，讨论了生物碱的生物作用与膜稳定作用和针对癌症治疗中由X射线照射或丝裂霉素治疗引起的白细胞减少症的保护作用。
Biscoclaurine-type alkaloids were examined for ability to act as membrane-stabilizing agents and to protect against lipid peroxidation and deterioration of biological membrane. The following results were obtained. Biscoclaurine-type alkaloids inhibit Fe2+-induced lipid peroxidation of biological membrane. Cepharanthine protects against decrease in membrane compartmentation due to Fe2+-induced lipid peroxidation. Peroxidation of membrane lipid causes decrease in membrane fluidity but cepharanthine protects against this decrease. These protective actions are structure specific. They are also biscoclaurine-type specific and do not apply to coclaurine-type alkaloids such as papaverine. Based on these findings, the biological action of the alkaloid is discussed relative to membrane-stabilizing action and protective action against leukopenia induced by X-ray irradiation or mitomycin treatment in cancer therapy.