Opsin-like immunoreaction in the retinae and pineal organs of four mammalian species
Opsin-like immunoreaction in the retinae and pineal organs of four mammalian species
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四种哺乳动物的视网膜和松果体器官中的视蛋白样免疫反应
DOI：
10.1007/bf00225432
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发表时间：
2004
影响因子：
3.6
通讯作者：
J. Schalken
中科院分区：
文献类型：
--
作者：
H. Korf;R. Foster;P. Ekström;J. Schalken
摘要在小鼠、大鼠和豚鼠的视网膜和松果体器官以及猫的松果体器官中观察到视蛋白样免疫反应性。在视网膜中，免疫反应仅限于感光细胞，这些细胞在其核周以及外节和内节中显示出免疫染色。在小鼠和猫的松果体器官中标记了具有特征过程的独特松果体细胞。然而，猫中免疫反应性松果体细胞的数量非常有限。在大鼠和豚鼠的松果体器官中，免疫反应非常弱且弥漫。当抗体用纯化的牛(rhod)视蛋白预吸收时，没有观察到免疫反应。这些发现与之前的研究结果一致，表明哺乳动物视网膜感光器和松果体细胞之间存在分子相似性。
SummaryOpsin-like immunoreactivity was observed in the retinae and pineal organs of the mouse, rat and guinea pig, and the pineal organ of the cat. In the retina the immunoreaction was restricted to photoreceptor cells, which displayed immunostaining in their perikarya and outer and inner segments. Distinct pinealocytes endowed with characteristic processes were labelled in the pineal organs of the mouse and cat. However, in the cat the number of immunoreactive pinealocytes was very limited. In the pineal organs of the rat and guinea pig immunoreaction was very weak and diffuse. No immunoreaction was observed when the antibody was preabsorbed with purified bovine (rhod)opsin. These findings are in accord with the results of previous studies indicating molecular similarities between retinal photoreceptors and pinealocytes in mammals.