NARCOTIC-ANTAGONISTS ATTENUATE DRINKING INDUCED BY WATER-DEPRIVATION IN A PRIMATE
NARCOTIC-ANTAGONISTS ATTENUATE DRINKING INDUCED BY WATER-DEPRIVATION IN A PRIMATE
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DOI：
10.1016/0024-3205(81)90455-0
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发表时间：
1981-01-01
期刊：
影响因子：
6.1
通讯作者：
HOLTZMAN, SG
中科院分区：
文献类型：
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作者：
BROWN, DR;HOLTZMAN, SG
纯麻醉性拮抗剂，如纳洛酮和纳曲酮，持续减少大鼠在一段时间的缺水后的饮酒。观察扩展到一种灵长类物种，松鼠猴(Saimiri Scureus)。纳洛酮和纳曲酮对阿片受体的相对亲和力高于对内源性阿片肽的高亲和力，前者优先结合吗啡和其他阿片生物碱，而另一种纯阿片受体拮抗剂异丙诺啡对这两种受体亚型的亲和力同样高。测定了地普诺平对缺水大鼠和松鼠猴的饮水作用，并与纳洛酮和纳曲酮进行了比较。3种麻醉性拮抗剂均能抑制猴和大鼠缺水18 h和24 h的水消耗。双丙诺啡是在两个物种中测试的最有效的化合物，在全身剂量分别为0.01 mg/kg和0.1 mg/kg时，显著减少了猴子和大鼠的用水量。丙泊诺啡是3种药物中作用时间最长的一种。麻醉性拮抗剂减少了灵长类动物和啮齿类动物的饮酒，并支持这样的假设，即这些药物通过阻断调节饮酒行为的内源性阿片途径的活动来减少水的摄入量。
Pure narcotic antagonists such as naloxone and naltrexone consistently attenuate drinking in the rat after periods of water deprivation. Observations were extended to a primate species, the squirrel monkey (Saimiri sciureus). Whereas naloxone and naltrexone have a greater relative affinity for opiate receptors preferentially binding morphine and other opiate alkaloids than for those with high affinity for the endogenous opiold peptides, diprenorphine, another pure opiate antagonist, binds with equally high affinity to both receptor subtypes. The actions of diprenorpine were determined on drinking in water-deprived rats and squirrel monkeys and the effects of this drug compared to those of naloxone and naltrexone. All 3 narcotic antagonists suppressed water comsumption of monkeys and rats deprived of water for 18 and 24 h, respectively. Diprenorphine was the most potent compound tested in both species, producing significant reductions in water consumption of monkeys and rats at systemic doses as low as 0.01 and 0.1 mg/kg, respectively. Diprenorphine was the longest acting of the 3 drugs in the monkey. The narcotic antagonists attenuate drinking in primates well as in rodents and support the hypothesis that these drugs reduce water intake by interrupting the activity of endogenous opioid pathways mediating drinking behavior.