VITAMIN-C, COMMON COLD, AND IRON-ABSORPTION
VITAMIN-C, COMMON COLD, AND IRON-ABSORPTION
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DOI：
10.1093/ajcn/30.2.235
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发表时间：
1977-01-01
影响因子：
7.1
通讯作者：
MONSEN, ER
中科院分区：
文献类型：
--
作者：
COOK, JD;MONSEN, ER
相当一部分人服用大量维生素 C 以减少上呼吸道感染的数量或严重程度。为了确定这种补充剂对铁平衡的影响，对 63 名男性受试者进行了多次放射性铁吸收测试。半合成粗粉中铁吸收的增加与抗坏血酸添加量成正比，范围为 25-1000 毫克。在这两个极端情况下，有/没有抗坏血酸的 Fe 吸收比率分别为 1.65 和 9.57。当测试餐含有肉类时，相对增加要少得多。早餐服用大剂量维生素 C 不会影响中午或晚上膳食中铁的吸收。对 100 人进行的电话调查显示，其中 67 人每天服用抗坏血酸补充剂，剂量高达 2 克。该人群平均每天补充抗坏血酸摄入量为 280 毫克。如果仅与早餐一起服用，这种补充水平将使每天吸收的铁量增加近 2 倍。如果每餐分次服用，铁的吸收量将增加3倍以上。
A sizable segment of the population was taking large quantities of vitamin C to reduce the number or severity of upper respiratory infections. To determine the affect of this supplementation on Fe balance, multiple radioiron absorption tests were performed in 63 male subjects. The increase in Fe absorption from a semisynthetic meal was directly proportional to the amount of ascorbic acid added over a range of 25-1000 mg. The ratio of Fe absorption with/without ascorbic acid at these 2 extremes was 1.65 and 9.57, respectively. The relative increase was substantially less when the test meal contained meat. A large dose of vitamin C taken with breakfast did not effect Fe absorption from the noon or evening meal. A telephone survey of 100 individuals revealed that 67 were taking supplemental ascorbic acid in doses ranging as high as 2 g daily. The average intake of supplemental ascorbic acid in this population was 280 mg daily. If taken only with breakfast, this level of supplementation would produce a nearly 2-fold increase in the amount of Fe absorbed daily. If taken in divided doses with each meal, the increase in Fe absorption would be more than 3-fold.