In vivo plaque characterization using intravascular ultrasound-virtual histology in a porcine model of complex coronary lesions
In vivo plaque characterization using intravascular ultrasound-virtual histology in a porcine model of complex coronary lesions
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DOI：
10.1161/01.atv.0000253907.51681.0e
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发表时间：
2007-02-01
影响因子：
8.7
通讯作者：
Kaluza, Greg L.
中科院分区：
文献类型：
--
作者：
Granada, Juan F.;Wallace-Bradley, David;Kaluza, Greg L.
目的 - 确定血管内超声-虚拟组织学（IVUS-VH）在复杂冠状动脉病变猪模型中检测不同组织类型的准确性。方法和结果 - 通过将含有人氧化低密度脂蛋白的脂质体注射到动脉外膜中诱导冠状动脉病变。注射后 8.2 +/- 1.6 周进行体内 IVUS-VH 成像。总共分析了 60 个血管病变，并与其相应的 IVUS-VH 图像进行了比较。使用线性回归模型进行相关分析。与组织学相比，IVUS-VH 正确识别病变组织中纤维组织、纤维脂肪组织和坏死组织的存在率分别为 58.33%、38.33% 和 38.33%。 IVUS-VH 检测纤维、纤维脂肪和坏死核心组织的灵敏度分别为 76.1%、46% 和 41.1%。对每个单独的斑块成分进行的线性回归分析没有显示出强烈的相关性，无法对个体值进行显着预测。结论 - 在复杂冠状动脉病变的猪模型中，IVUS-VH 在检测每个个体相应组织学标本中特定斑块成分的相对量时并不准确。
Objective - To determine the accuracy of detection of different tissue types of intravascular ultrasound - virtual histology (IVUS-VH) in a porcine model of complex coronary lesions.Methods and Results - Coronary lesions were induced by injecting liposomes containing human oxidized low-density lipoprotein into the adventitia of the arteries. IVUS-VH imaging was performed in vivo at 8.2 +/- 1.6 weeks after injection. A total of 60 vascular lesions were analyzed and compared with their correspondent IVUS-VH images. Correlation analysis was performed using linear regression models. Compared with histology, IVUS-VH correctly identified the presence of fibrous, fibro-fatty, and necrotic tissue in 58.33%, 38.33%, and 38.33% of lesions, respectively. The sensitivity of IVUS-VH for the detection of fibrous, fibro-fatty, and necrotic core tissue was 76.1%, 46%, and 41.1% respectively. A linear regression analysis performed for each individual plaque component did not show strong correlation that would allow significant prediction of individual values.Conclusions - In a porcine model of complex coronary lesions, IVUS-VH was not accurate in detecting the relative amount of specific plaque components within each individual corresponding histological specimen.