Effects of bifidobacterium breve supplementation on intestinal flora of low birth weight infants
Effects of bifidobacterium breve supplementation on intestinal flora of low birth weight infants
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DOI：
10.1111/j.1442-200x.2004.01953.x
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发表时间：
2004-10-01
影响因子：
1.4
通讯作者：
Yamashiro, Y
中科院分区：
文献类型：
--
作者：
Li, YD;Shimizu, T;Yamashiro, Y
背景：已知双歧杆菌植物群在粘膜宿主防御中起重要作用，可预防感染性疾病。由于细菌种群在生命的第一天发展，作者研究了早期给予双歧杆菌是否对低出生体重儿的健康有积极影响。Breve）补充剂在低出生体重婴儿（平均出生体重1489 g）的对照试验中进行了研究。婴儿被分为三组：A组和B组接受1.6 × 10（8）个细胞的B。每天2次，从生后数小时（A组）或生后24小时（B组）开始。结果：3组新生儿出生体重、抗生素使用情况、母乳喂养开始时间均无显著性差异（P> 0.05）。A组平均在出生后2周形成双歧杆菌优势植物群，B组平均在出生后4周形成双歧杆菌优势菌群，而C组在7周的观察期内10名婴儿中有8名未分离出双歧杆菌。A组双歧杆菌检出时间明显早于B组，2周时肠杆菌科细菌检出率明显低于B组。结论：B组早期应用双歧杆菌是一种有效的治疗方法。短至低出生体重婴儿可用于促进双歧杆菌的定植和正常肠道植物群的形成。
Background: It is known that the bifidobacteria flora play important roles in mucosal host defense and can prevent infectious diseases. Because bacterial populations develop during the first day of life, the authors examined whether the early administration of bifidobacteria has a positive effect on the health of low birth weight infants.Methods: The effects of oral administration of Bifidobacterium breve (B. breve) supplements were studied in a controlled trial with low birth weight infants (average birth weight 1489 g). The infants were divided into three groups: Group A and B received a dose of 1.6 x 10(8) cells of B. breve supplement twice a day, commencing either from several hours after birth (group A) or 24 h after birth (group B). Group C, the control group, received no supplement.Results: There were no significant differences in birth weight, treatment with antibiotics, and the starting time of breast-feeding among the three groups. A Bifidobacterium-predominant flora was formed at an average of 2 weeks after birth in group A and at an average of 4 weeks after birth in group B, while no Bifidobacterium was isolated in eight out of 10 infants in group C during the observation period of 7 weeks. In comparison between group A and B, Bifidobacterium was detected significantly earlier in group A, and the number of Enterobacteriaceae present in the infants at 2 weeks after birth was significantly lower in group A.Conclusion: The results of the present study suggest that very early administration of B. breve to low birth weight infants is useful in promoting the colonization of the Bifidobacterium and the formation of a normal intestinal flora.