Skin microbiome: looking back to move forward.
Skin microbiome: looking back to move forward.
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DOI：
10.1038/jid.2011.417
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发表时间：
2012-03
期刊：
影响因子：
--
通讯作者：
Segre JA
中科院分区：
文献类型：
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作者：
Kong HH;Segre JA
数以万亿计的细菌、真菌、病毒、古细菌和小型节肢动物定植于皮肤表面，共同构成了皮肤微生物组。一代又一代的研究人员将这些微生物分为瞬时微生物与常驻微生物、有益微生物与致病微生物、合作者与对手。对微生物居民的培养和直接测序确定了皮肤表面部位存在的不同种群。在此，我们探讨了该领域的历史，描述了当前分子测序时代的发现，并考虑了研究微生物和抗菌疗法如何对人类健康做出贡献的未来。
Trillions of bacteria, fungi, viruses, archaea and small arthropods colonize the skin surface, collectively comprising the skin microbiome. Generations of researchers have classified these microbes as transient versus resident, beneficial versus pathogenic, collaborators versus adversaries. Culturing and direct sequencing of microbial inhabitants identified distinct populations present at skin surface sites. Herein, we explore the history of this field, describe findings from the current molecular sequencing era, and consider the future of investigating how microbes and antimicrobial therapy contribute to human health.