Capacity of mammary fat pads of adult C3H/HeMs mice to interact morphogenetically with fetal mammary epithelium.
Capacity of mammary fat pads of adult C3H/HeMs mice to interact morphogenetically with fetal mammary epithelium.
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成年 C3H/HeMs 小鼠乳腺脂肪垫与胎儿乳腺上皮形态发生相互作用的能力。
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
C. Dawe
中科院分区：
文献类型：
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作者：
T. Sakakura;Y. Nishizuka;C. Dawe
将13~17d雌性C3H/HEMS胚胎的基本乳腺上皮移植到3周龄小鼠的无腺体乳脂垫中，移植物发生器官发生发育，与正常乳腺形态发生相似。最初的发育生长不需要生殖激素。幼年(3周龄)、青壮年(8~12周龄)和完全成熟(40周龄)女性的乳房脂肪垫在形态上与胎儿乳腺上皮相互作用的能力相同。胎儿肺、胰腺和唾液腺上皮在成人乳房脂肪中没有形态发生反应。一个例外是发育不全的毛囊上皮，它在乳房脂肪内向毛囊广泛发育。将发育的乳腺上皮细胞移植到无腺体脂肪垫中，当宿主生育幼崽时，乳腺发生了以哺乳为特征的形态变化。
When rudimentary mammary epithelium from 13- to 17-day female C3H/HeMs fetuses was transplanted into gland-free mammary fat pads of 3-week-old mice, organogenetic development of the grafts occurred, resembling that seen in normal mammary gland morphogenesis. Initial developmental growth did not require the reproductive hormones. Mammary fat pads of juvenile (3-wk-old), young adult (8- to 12-wk-old), and fully matured (40-wk-old) females had equal ability to interact morphogenetically with fetal mammary epithelium. Fetal pulmonary, pancreatic, and salivary gland epithella showed no morphogenetic response within adult mammary fat. An exception was rudimentary hair follicle epithellum, which underwent extensive development toward hair follicles within mammary fat. Mammary glands that developed from rudimentary mammary epithellum transplanted into gland-free fat pads underwent morphologic changes characteristic of lactation when the hosts bore young.