Secondary metabolites from Andrographis paniculata
Secondary metabolites from Andrographis paniculata
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DOI：
10.1248/cpb.55.455
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发表时间：
2007-03-01
影响因子：
1.7
通讯作者：
Fitzloff, John
中科院分区：
文献类型：
--
作者：
Li, Wenkui;Xu, Xudong;Fitzloff, John
两种新的黄酮苷，5-羟基-7,8-二甲氧基 (2R)-黄烷酮-5-O-β-D-吡喃葡萄糖苷 (1) 和 5-羟基-7,8,2',5'-四甲氧基-黄酮-5-O-β-D-吡喃葡萄糖苷 (2)，以及一种新的二萜类穿心莲酸 (3)以及穿心莲苷A(4)是从穿心莲中分离出来的，并根据物理化学和光谱分析确定了它们的结构。在本研究中，评估了化合物3与从A.paniculata获得的穿心莲内酯、异穿心莲内酯、新穿心莲内酯和14-脱氧-11,12-二氢化穿心莲内酯对KB细胞的细胞毒性。观察到穿心莲内酯和异穿心莲内酯的细胞毒性，ED50 值分别为 6.5 和 5.1 μg/ml。
Two new flavonoid glycosides, 5-hydroxy-7,8-dimethoxy (2R)-flavanone-5-O-beta-D-glucopyranoside (1) and 5-hydroxy-7,8,2',5'-tetramethoxy-flavone-5-O-beta-D-glucopyranoside (2), and a new diterpenoid, andrographic acid (3), along with andrographidine A (4) were isolated from Andrographis paniculata, and their structures were determined on the basis of physicochemical and spectroscopic analysis. Compound 3 was evaluated for cytotoxicity to KB cells along with andrographolide, isoandrographolide, neoandrographolide and 14-deoxy-11,12-didehyd roandrographolide obtained from A. paniculata in the present study. Cytotoxicity was observed for andrographolide and isoandrographolide with ED50 values of 6.5 and 5.1 mu g/ml, respectively.