The circadian neutrophil, inside-out.
The circadian neutrophil, inside-out.
复制标题
昼夜节律中性粒细胞，由内而外。
DOI：
10.1093/jleuko/qiad038
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发表时间：
2023
影响因子：
5.5
通讯作者：
Hidalgo,Andrés
中科院分区：
文献类型：
--
作者：
Ovadia,Samuel;Özcan,Alaz;Hidalgo,Andrés
生物钟影响着无数的生理目标，其中免疫和炎症系统尤为突出。在这篇综述中，我们讨论了中性粒细胞，免疫系统的细胞，是如何调节昼夜节律振荡。我们描述了细胞内在和外在的昼夜机制，这些细胞的一般生理和功能，从纯粹的免疫稳态。重新利用在其他细胞类型中发现的概念，然后我们推测各种未知的生物钟-昼夜节律关系的途径，例如拓扑结构，代谢和组织时钟的调节，希望在昼夜节律免疫的背景下确定令人兴奋的新工作途径。
The circadian clock has sway on a myriad of physiological targets, among which the immune and inflammatory systems are particularly prominent. In this review, we discuss how neutrophils, the wildcard of the immune system, are regulated by circadian oscillations. We describe cell-intrinsic and extrinsic diurnal mechanisms governing the general physiology and function of these cells, from purely immune to homeostatic. Repurposing the concepts discovered in other cell types, we then speculate on various uncharted avenues of neutrophil–circadian relationships, such as topology, metabolism, and the regulation of tissue clocks, with the hope of identifying exciting new avenues of work in the context of circadian immunity.