Effects of chronic social stress in adolescence on anxiety and neuroendocrine response to mild stress in male and female rats
Effects of chronic social stress in adolescence on anxiety and neuroendocrine response to mild stress in male and female rats
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DOI：
10.1016/j.bbr.2007.09.005
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发表时间：
2008-03-05
影响因子：
2.7
通讯作者：
Mathews, I. Z.
中科院分区：
文献类型：
--
作者：
McCormick, C. M.;Smith, C.;Mathews, I. Z.
使用青少年社会压力大鼠模型（SS，每天 1 小时隔离并更换笼中伴侣，30-45 天龄），我们报告了 SS 过程中对神经内分泌功能的性别特异性影响，以及 SS 对雌性（而非雄性）毒品相关行为的持久影响。在这里，我们研究了青春期 SS 对高架十字迷宫 (EPM) 中焦虑样行为的直接和持久影响，并确定了限制在 EPM 开放臂后皮质酮释放的时间模式。当青少年时期进行测试时。 SS 减少了女性的焦虑样行为，但对男性没有影响。当成年后在慢性压力几周后进行测试时，总体而言，SS 往往会增加男女的焦虑样行为。然而，发情周期缓和了对雌性的影响，因为在发情组中观察到 SS 雌性的焦虑样行为减少。限制在 EPM 的开放臂中会增加血浆皮质酮浓度，除了青少年对照雄性之外，所有雄性在返回笼子后血浆皮质酮浓度均显着下降，与其他组相比，青春期对照雄性在 45 分钟和 90 分钟时的皮质酮浓度升高。在对照组中，随着年龄的增长，女性的焦虑样行为减少，男性的焦虑样行为增加，并且与青少年男性相比，限制在 EPM 的张开臂中导致成年男性皮质酮浓度的增加更大。总之。在压力暴露几周后，可以观察到青少年社会压力的适度影响，这表明特定性别的发展轨迹和易受焦虑的影响可能是由青春期的经历决定的。 (C) 2007 Elsevier B.V. 保留所有权利。
Using a rat model of adolescent social stress (SS, daily 1 h isolation and change of cage partner, 30-45 days of age), we have reported sex-specific effects on neuroendocrine function over the course of SS, and enduring effects of SS in females, and not males, on drug-related behaviour. Here, we investigated both the immediate and enduring impact of SS in adolescence on anxiety-like behaviour in the elevated plus maze (EPM) and determined the temporal pattern of corticosterone release after confinement to the open arm of the EPM. When tested as adolescents. SS decreased anxiety-like behaviour in females and had no effect in males. When tested as adults several weeks after the chronic stress, overall, SS tended to increase anxiety-like behaviour in both sexes. However, estrous cycle moderated the effect in females, in that reduced anxiety-like behaviour was observed for SS females in the estrous group. Confinement to the open arm of the EPM increased plasma corticosterone concentrations, which declined markedly upon return to home cage for all except adolescent control males for which corticosterone concentrations at 45 and 90 min were elevated compared other groups. Among controls, anxiety-like behaviour decreased in females and increased in males with age, and confinement to the open arm of the EPM led to a greater increase in corticosterone concentrations in adult males compared to adolescent males. In sum. modest effects of adolescent social stress were observable several weeks after the stress exposure, indicating that sex-specific developmental trajectories and vulnerability to anxiety may be shaped by experiences in adolescence. (C) 2007 Elsevier B.V. All rights reserved.