SACCADES IN HUNTINGTONS-DISEASE - INITIATION DEFECTS AND DISTRACTIBILITY
SACCADES IN HUNTINGTONS-DISEASE - INITIATION DEFECTS AND DISTRACTIBILITY
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DOI：
10.1212/wnl.37.3.364
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发表时间：
1987-03-01
期刊：
影响因子：
9.9
通讯作者：
SINGER, HS
中科院分区：
文献类型：
--
作者：
LASKER, AG;ZEE, DS;SINGER, HS
我们记录了轻度亨廷顿病患者的扫视眼球运动。大多数人表现出增加眼跳lastness是更大的眼跳命令比突然出现的视觉目标。所有患者在尝试固定时均表现出过度的注意力分散。当他们同时试图向相反方向发起扫视时，他们特别难以抑制对突然出现的视觉目标的扫视。我们的研究结果与基底神经节在自主性扫视的启动和固定的维持中的假定作用是一致的。扫视异常，尤其是注意力分散，是亨廷顿病的敏感指标，但可能不是特异性指标。
We recorded saccadic eye movements in patients mildly affected with Huntington''s disease. Most showed an increase in saccade latencies that was greater for saccades made on command than to the sudden appearance of a visual target. All patients showed excessive distractibility during attempted fixation. They had particular difficulty suppressing a saccade to a suddenly appearing visual target when simultaneously trying to initiate a saccade in the opposite direction. Our results are compatible with a posited role of the basal ganglia in both the initiation of volitional saccades and in the maintenance of fixation. Saccade abnormalities.sbd.especially distractibility.sbd.are sensitive but probably not specific indicators of Huntington''s disease.