Fatigue in multiple sclerosis - Reciprocal relationships with physical disabilities and depression
Fatigue in multiple sclerosis - Reciprocal relationships with physical disabilities and depression
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DOI：
10.1016/s0022-3999(02)00326-4
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发表时间：
2002-09-01
影响因子：
4.7
通讯作者：
Bensing, JM
中科院分区：
文献类型：
--
作者：
Schreurs, KMG;de Ridder, DTD;Bensing, JM
目的：从横断面和时间角度探讨多发性硬化症 (MS) 患者疲劳、身体残疾和抑郁的关系。方法：对 98 名 MS 患者进行两次访谈，间隔一年。通过回归分析建立横断面的身体和精神疲劳以及活动和动机减少与抑郁和身体残疾的关系，并通过结构方程模型建立纵向关系。结果：从横断面来看，身体疲劳与身体残疾相关，精神疲劳与抑郁相关。前瞻性地，身体疲劳是一年后身体残疾的预测因素。然而，身体残疾与一年后身体疲劳的反向关系并不显着，而抑郁则预测一年后的身体疲劳和活动减少。抑郁症不能预测后来的精神疲劳，之前的疲劳经历也不能预测抑郁症。结论：多发性硬化症患者的疲劳应该随着时间的推移进行研究，因为一年中疲劳与身心健康的关系会发生变化。此外，区分疲劳经历可以揭示疲劳与身心健康的关系。 (C) 2002 Elsevier Science Inc. 保留所有权利。
Objective: To explore relations of fatigue, physical disabilities, and depression in patients with multiple sclerosis (MS) cross-sectionally and over time.Methods: Ninety-eight MS patients were interviewed twice at an interval of a year. Relationships of physical and mental fatigue, and reduced activity and motivation with depression and physical disabilities were established cross-sectionally by regression analyses and longitudinally by structural equation modelling.Results: Cross-sectionally, physical fatigue was related with physical disabilities, and mental fatigue was associated with depression. Prospectively, physical fatigue was a predictor of the physical disabilities of a year later. The reverse relationship of physical disabilities predicting the physical fatigue of one year later was, however, not significant, while depression predicted this physical fatigue and reduced activity of a year later. Depression did not predict the later mental fatigue nor was depression predicted by preceding fatigue experiences.Conclusions: Fatigue in MS should be studied over time as relationships of fatigue with physical and mental health change during the course of a year. Moreover, differentiating in fatigue experiences sheds light on the relationship of fatigue with physical and mental health. (C) 2002 Elsevier Science Inc. All rights reserved.