An overview of the oxytocin-oxytocin receptor signaling network
An overview of the oxytocin-oxytocin receptor signaling network
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DOI：
10.1007/s12079-016-0353-7
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发表时间：
2016-12-01
影响因子：
4.1
通讯作者：
Prasad, T. S. Keshava
中科院分区：
文献类型：
--
作者：
Chatterjee, Oishi;Patil, Krutika;Prasad, T. S. Keshava
催产素是一种九个氨基酸长的神经肽激素，在下丘脑中合成，并从脑垂体的神经叶储存和释放。尽管催产素通常以其在分娩和哺乳调节中的核心作用而闻名，但催产素信号传导在调节人类和动物的社会行为、唤起满足感、启动母性行为、诱导信任、慷慨和结合方面也起着关键作用。催产素信号传导可以证明是非常重要的治疗和药物靶向，因为它的各种各样的行动。然而，一个很好的注释催产素信号通路的地图是目前缺乏公开可用的途径资源。因此，我们从已发表的文献中系统地收集了催产素的可用信号信息，并整理了数据以开发更完整的图谱。我们编目了66个属于催产素信号通路的分子，其中包括9个蛋白质-蛋白质相互作用、39个翻译后修饰、14个蛋白质易位事件和22个激活/抑制事件。此外，催产素信号网络数据通过将其整合到NetPath（http：//www.netpath.org/）中而免费提供给学术界，NetPath是我们小组先前开发的免费可用的人类信号通路资源。
Oxytocin, a nine amino acid long neuropeptide hormone, is synthesized in the hypothalamus and stored and released from the neural lobe of the pituitary gland. Although commonly known for its central role in the regulation of parturition and lactation, oxytocin signaling also plays a key role in modulating social behavior, evoking contentment, initiating maternal behavior, inducing trust, generosity and bonding in humans and animals. Oxytocin signaling can prove to be of great importance in therapeutics and drug targeting because of its diverse range of actions. However, a well annotated map of oxytocin signaling pathway is currently lacking in the publicly available pathway resources. Therefore, we systematically cu-rated the available signaling information of oxytocin from published literature and collated the data to develop a more complete map. We cataloged 66 molecules belonging to oxytocin signaling pathway, which included 9 protein-protein interactions, 39 post-translational modifications, 14 protein translocation events and 22 activation/inhibition events. Further, Oxytocin signaling network data is made freely available to academic fraternity by integrating this into NetPath (http://www.netpath.org/), a freely available human signaling pathway resource developed previously by our group.