Bacterial Proprioception: Can a Bacterium Sense Its Movement?
Bacterial Proprioception: Can a Bacterium Sense Its Movement?
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细菌本体感受：细菌能感觉到它的运动吗？
DOI：
10.3389/fmicb.2022.928408
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发表时间：
2022
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
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作者：
细菌鞭毛的进化引起了一个信号网络的运动和再利用，现在被称为趋化性网络，使细胞运动的偏见。这使得细菌有可能寻找有利的化学环境。为了实现趋化性，趋化性网络敏感地检测细胞外化学刺激并适当地调节鞭毛功能。此外，鞭毛马达本身能够检测机械刺激，并调整其结构和功能，以作出反应，可能引发从兴奋性到表面相关的生活方式的转变。最近的工作表明鞭毛马达对机械刺激的反应和趋化性输出之间存在联系。在这里，我们详细阐述了这种联系，并讨论了它如何帮助细胞感知和适应不同环境中游泳速度的变化。我们讨论的机制，使电机精确地调整其趋化性输出不同的机械负荷下，类似于在高阶生物体的本体感受。我们推测细菌本体感受可能在各种现象中发挥的作用，包括向表面相关生活方式的过渡，如群集和生物膜。
The evolution of the bacterial flagellum gave rise to motility and repurposing of a signaling network, now termed the chemotaxis network, enabled biasing of cell movements. This made it possible for the bacterium to seek out favorable chemical environments. To enable chemotaxis, the chemotaxis network sensitively detects extracellular chemical stimuli and appropriately modulates flagellar functions. Additionally, the flagellar motor itself is capable of detecting mechanical stimuli and adapts its structure and function in response, likely triggering a transition from planktonic to surface-associated lifestyles. Recent work has shown a link between the flagellar motor’s response to mechanical stimuli and the chemotactic output. Here, we elaborate on this link and discuss how it likely helps the cell sense and adapt to changes in its swimming speeds in different environments. We discuss the mechanism whereby the motor precisely tunes its chemotaxis output under different mechanical loads, analogous to proprioception in higher order organisms. We speculate on the roles bacterial proprioception might play in a variety of phenomena including the transition to surface-associated lifestyles such as swarming and biofilms.
大肠杆菌群中的切换和转矩生成
影响因子：
5.2
作者：
Ford KM;Antani JD;Nagarajan A;Johnson MM;Lele PP
通讯作者：
Lele PP