Chronic psychological stress and its impact on the development of aggressive breast cancer.
Chronic psychological stress and its impact on the development of aggressive breast cancer.
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DOI：
10.1590/s1679-45082015ao3344
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发表时间：
2015-07
期刊：
影响因子：
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通讯作者：
Panis C
中科院分区：
文献类型：
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作者：
Cormanique TF;Almeida LE;Rech CA;Rech D;Herrera AC;Panis C
探讨乳腺癌患者的临床病理特征，探讨慢性心理应激对乳腺癌病理特征的影响。 我们调查了一个由诊断为乳腺癌的妇女组成的队列，并分为两组。一组被归类为慢性心理压力（通过使用自我报告问卷-SRQ-20）。另一组患有乳腺癌的妇女，但以前没有慢性心理压力的历史，组成了对照组。评估临床和病理学数据。 与对照组相比，有慢性痛苦史的妇女体重明显超重。此外，还观察到这些有压力的女性也有很大比例的侵袭性乳腺癌亚型，即HER 2扩增肿瘤，这可能与免疫监视的丧失有关。 我们的研究结果表明，慢性心理压力，超重和更具侵略性的乳腺肿瘤的发展之间的相互作用。
To investigate the clinicopathological findings of women diagnosed with breast cancer and study the impact of chronic psychological stress on the pathological characteristics of these tumors. We investigated a cohort composed of women diagnosed with breast cancer and divided into two groups. One group was categorized as presenting with chronic psychological stress (by using the Self-Reporting Questionnaire − SRQ-20). Another group of women with breast cancer, but with no previous history of chronic psychological stress, comprised the Control Group. Clinical and pathological data were assessed. Women presenting with a history of chronic distress were significantly overweight when compared to the Control Group. Furthermore, it was observed that these stressed women also had a significant percentage of aggressive breast cancer subtype, the HER2 amplified tumor, which could be putatively associated with the loss of immunosurveillance. Our findings suggested an interaction among chronic psychological stress, overweight, and the development of more aggressive breast tumors.