Functional neuroanatomy of human rapid-eye-movement sleep and dreaming
Functional neuroanatomy of human rapid-eye-movement sleep and dreaming
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DOI：
10.1038/383163a0
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发表时间：
1996-09-12
期刊：
影响因子：
64.8
通讯作者：
Franck, G
中科院分区：
文献类型：
--
作者：
Maquet, P;Peters, JM;Franck, G
快速眼动 (REM) 睡眠与强烈的神经元活动、眼跳、肌肉无力和做梦有关(1,2)。快速眼动睡眠的功能仍然难以捉摸，其神经相关性在人类中尚未得到精确表征。在这里，我们使用正电子发射断层扫描和统计参数映射来研究与人类快速眼动睡眠相关的大脑状态。我们报告了一项针对七名受试者的小组研究，这些受试者在大脑扫描期间保持稳定的快速眼动睡眠，并在醒来时回忆起梦境。结果表明，脑桥被盖、左侧丘脑、双杏仁复合体、前扣带皮层和右侧顶叶盖的局部脑血流量与快速眼动睡眠呈正相关。在双侧、背外侧前额叶皮质、顶叶皮质（缘上回）以及后扣带皮层和楔前叶的大片区域中，观察到局部脑血流量与快速眼动睡眠之间的负相关性。鉴于杏仁核复合体在获得受情绪影响的记忆中的作用，杏仁核和皮质区域的激活模式为快速眼动睡眠期间某些类型的记忆的处理提供了生物学基础。
RAPID-EYE-MOVEMENT (REM) sleep is associated with intense neuronal activity, ocular saccades, muscular atonia and dreaming(1,2). The function of REM sleep remains elusive and its neural correlates have not been characterized precisely in man. Here we use positron emission tomography and statistical parametric mapping to study the brain state associated with REM sleep in humans. We report a group study of seven subjects who maintained steady REM sleep during brain scanning and recalled dreams upon awakening. The results show that regional cerebral blood flow is positively correlated with REM sleep in pontine tegmentum, left thalamus, both amygdaloid complexes, anterior cingulate cortex and right parietal operculum. Negative correlations between regional cerebral blood flow and REM sleep are observed bilaterally, in a vast area of dorsolateral prefrontal cortex, in parietal cortex (supramarginal gyrus) as well as in posterior cingulate cortex and precuneus. Given the role of the amygdaloid complexes in the acquisition of emotionally influenced memories, the pattern of activation in the amygdala and the cortical areas provides a biological basis for the processing of some types of memory during REM sleep.