Toll-like receptor 4-dependent activation of dendritic cells by β-defensin 2
Toll-like receptor 4-dependent activation of dendritic cells by β-defensin 2
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DOI：
10.1126/science.1075565
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发表时间：
2002-11-01
期刊：
影响因子：
56.9
通讯作者：
Kwak, LW
中科院分区：
文献类型：
--
作者：
Biragyn, A;Ruffini, PA;Kwak, LW
β-防御素是天然免疫系统中的一种小分子抗菌肽，是针对黏膜组织和皮肤的微生物感染而产生的。我们证明，小鼠β-防御素2(MDF2beta)直接作用于未成熟的树突状细胞，作为Toll样受体4(TLR-4)的内源性配体，诱导共刺激分子的上调和树突状细胞的成熟。这些事件反过来在体内触发强健的1型极化适应性免疫反应，表明mDF2β可能在针对病原体的免疫监控中发挥重要作用，可能还包括自身抗原或肿瘤抗原。
beta-Defensins are small antimicrobial peptides of the innate immune system produced in response to microbial infection of mucosal tissue and skin. We demonstrate that murine beta-defensin 2 (mDF2beta) acts directly on immature dendritic cells as an endogenous ligand for Toll-like receptor 4 (TLR-4), inducing up-regulation of costimulatory molecules and dendritic cell maturation. These events, in turn, trigger robust, type 1 polarized adaptive immune responses in vivo, suggesting that mDF2beta may play an important role in immunosurveillance against pathogens and, possibly, self antigens or tumor antigens.