Multiorgan WU Polyomavirus Infection in Bone Marrow Transplant Recipient.
Multiorgan WU Polyomavirus Infection in Bone Marrow Transplant Recipient.
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DOI：
10.3201/eid2201.151384
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发表时间：
2016-01
影响因子：
11.8
通讯作者：
Wang D
中科院分区：
文献类型：
--
作者：
Siebrasse EA;Nguyen NL;Willby MJ;Erdman DD;Menegus MA;Wang D
在一名死者的肺和气管中检测到病毒。WU多瘤病毒（WUPyV）在2001年死亡的严重急性呼吸窘迫综合征骨髓移植受者中检测到。通过电子显微镜在患者的肺中观察到多瘤病毒样颗粒的晶格。通过实时定量PCR检测肺和其他组织中的WUPyV，并通过免疫组织化学鉴定肺和气管中的WUPyV。肺中的WUPyV阳性细胞亚群具有巨噬细胞的形态学特征。尽管WUPyV作为人类病原体的作用仍不清楚，但这些结果清楚地证明了该患者呼吸道组织感染的证据。
Virus was detected in the lung and trachea of a deceased patient. WU polyomavirus (WUPyV) was detected in a bone marrow transplant recipient with severe acute respiratory distress syndrome who died in 2001. Crystalline lattices of polyomavirus-like particles were observed in the patient’s lung by electron microscopy. WUPyV was detected in the lung and other tissues by real-time quantitative PCR and identified in the lung and trachea by immunohistochemistry. A subset of WUPyV-positive cells in the lung had morphologic features of macrophages. Although the role of WUPyV as a human pathogen remains unclear, these results clearly demonstrate evidence for infection of respiratory tract tissues in this patient.