INFLUENCE OF AMPICILLIN, CLINDAMYCIN, AND METRONIDAZOLE ON FECAL EXCRETION OF SHORT-CHAIN FATTY-ACIDS IN HEALTHY-SUBJECTS
INFLUENCE OF AMPICILLIN, CLINDAMYCIN, AND METRONIDAZOLE ON FECAL EXCRETION OF SHORT-CHAIN FATTY-ACIDS IN HEALTHY-SUBJECTS
复制标题
DOI：
10.3109/00365528609003109
复制
发表时间：
1986-01-01
影响因子：
1.9
通讯作者：
STEINBAKK, M
中科院分区：
文献类型：
--
作者：
HOVERSTAD, T;CARLSTEDTDUKE, B;STEINBAKK, M
在6名健康受试者接受克林霉素、氨苄青霉素或甲硝唑口服6天之前、期间和之后，测量了短链脂肪酸（SCFA）的粪便排泄。克林霉素的摄入使SCFA的中位总浓度从62.9 mmol/kg粪便（湿重）降低至7.3 mmol/kg（p < 0.05）。在治疗期间，乙酸的相对量从总浓度的50%增加到90%（p < 0.05）。氨苄青霉素将SCFA浓度中位数从62.4 mmol/kg降低至47.8 mmol/kg（p < 0.05），而甲硝唑未显著改变SCFA浓度。所有受试者的SCFAs浓度在治疗后5周内恢复正常。治疗期间，在粪便中检测到高浓度的克林霉素。仅在一个粪便样品中检测到氨苄青霉素，该样品来自氨苄青霉素组中唯一没有可检测的β-内酰胺酶的受试者。粪便中的内酰胺酶活性。在接受该药物的任何受试者的粪便中均未检出甲硝唑。仅在一个粪便样品中检测到克林霉素和氨苄青霉素，该样品来自氨苄青霉素组中唯一没有可检测的β-内酰胺酶的受试者。粪便中的内酰胺酶活性。在接受该药物的任何受试者的粪便中均未检出甲硝唑。克林霉素和氨苄青霉素，但不是甲硝唑，诱导粪便SCFA的显着变化，最有可能反映了结肠生态系统的严重变化。抗生素对结肠菌群的影响可能部分取决于其抗菌谱和肠道中抗菌活性药物的浓度。
The faecal excretion of short-chain fatty acids (SCFAs) has been measured in groups of six healthy subjects before, during, and after they received the antibiotics clindamycin, ampicillin, or metronidazole perorally for 6 days. Intake of clindamycin reduced the median total concentration of SCFAs from 62.9 mmol/kg faeces (wet weight) to 7.3 mmol/kg (p < 0.05). During therapy the relative amounts of acetic acid increased from 50% to 90% of the total concentration (p < 0.05). Ampicillin reduced the median SCFAs concentration from 62.4 mmol/kg to 47.8 mmol/kg (p < 0.05), whereas metronidazole did not change the SCFAs concentrations significantly. The SCFAs concentrations returned to normal within 5 weeks after the treatment in all subjects. Clindamycin was detected in high concentrations in faeces during therapy. Ampicillin was detected in only one faecal sample, which was from the only subject in the ampicillin group without detectable .beta.-lactamase activity in faeces. Metronidazole could not be detected in faeces from any subjects receiving this drug. Clindamycin and ampicillin was detected in only one faecal sample, which was from the only subject in the ampicillin group without detectable .beta.-lactamase activity in faeces. Metronidazole could not be detected in faeces from any subjects receiving this drug. Clindamycin and ampicillin, but not metronidazole, induce pronounced changes in faecal SCFAs, most likely reflecting severe changes in the colonic ecosystem. An antibiotic''s influence on the colonic microflora may in part depend on its antimicrobial spectrum and the concentration of antimicrobially active drug in the gut.