EFFECT OF ZINC AND VITAMIN A SUPPLEMENTATION ALONG WITH INTERTUBERCULAR TREATMENT IN PULMONARY TUBERCULOSIS IN NORTH INDIAN PATIENTS
EFFECT OF ZINC AND VITAMIN A SUPPLEMENTATION ALONG WITH INTERTUBERCULAR TREATMENT IN PULMONARY TUBERCULOSIS IN NORTH INDIAN PATIENTS
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DOI：
10.13040/ijpsr.0975-8232.4(9).3426-31
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发表时间：
2013-09-01
期刊：
影响因子：
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通讯作者：
Al-Hazimi, Awdah M.
中科院分区：
文献类型：
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作者：
Ginawi, Ibrahim A. M.;Ahmed, Mohammed Q.;Al-Hazimi, Awdah M.
结核病是由结核分枝杆菌引起的世界范围内主要的公共卫生问题。结果表明，微量营养素缺乏在结核病患者中很常见。根据这项研究，新诊断的结核病患者被分为四组。一组 (n = 41) 接受安慰剂，第二组 (n = 47) 接受 5000 IU 维生素 A 视黄酯乙酸酯，第三组 (n = 49) 接受 15 毫克锌硫酸锌，第四组 (n = 41) 接受 5000 IU 维生素 A 视黄酯乙酸酯和 15 毫克锌硫酸锌。所有组均接受相同的抗结核治疗（ATT）。结果基线时各组之间的生化状态没有显着差异。 2个月后，各组痰涂片结核杆菌阴性患者人数几乎相等（A组90.6%、B组90.3%、C组91.4%和D组93.1%）。 ATT治疗2个月和6个月后，微量营养素组的血红蛋白、血清白蛋白、维生素A和锌浓度的增加显着高于安慰剂组。由此可见，补充微量营养素提高了抗结核药物在前2个月和第6个月的疗效。可以减少第一阶段和第二阶段治疗中的抗结核药物或引入较短的疗程。这种较短的疗程将导致更高的完成率、更少的药物不良反应和更低的 ATT 成本。
Tuberculosis is the major public health problem in throughout the world caused by Mycobacterium tuberculosis. Result indicates that micronutrient deficiency is common in patients with tuberculosis. As per in this study patients with newly diagnosed tuberculosis patients were divided into four groups. One group (n=41) received a placebo, second group (n=47) received 5000 IU vitamin A as retinyl acetate, third group (n=49) received 15 mg zinc as zinc sulphate and fourth group (n=41) received both 5000 IU vitamin A as retinyl acetate & 15 mg zinc as zinc sulphate. All groups received the same antituberculosis treatment (ATT). Results there were no significant differences in biochemical status amongst groups at baseline. After 2 months, the number of patients with sputum smears negative for tubercle bacilli was almost equal in all the groups (Group A-90.6%, Group B-90.3%, Group C-91.4% and Group D=93.1%). After 2 and 6 months of ATT, the increase in hemoglobin, serum albumin, vitamin A and zinc concentrations were significantly higher in the micronutrient group than in the placebo group. By which we can depict that the supplementation of micronutrient improved the effectiveness of antituberculosis drugs in the first 2 and 6 month. It may be possible to reduce the antituberculosis drugs in the first and second phase of treatment or to introduce a shorter regimen. Such a shorter regimen would lead to a higher completion rate, fewer drugs adverse effect and lower cost of ATT.